The effect of two quadruple diets of amoxicillin, bismuth, levofloxacin and pantoprazole versus amoxicillin, clarithromycin, bismuth, pantoprazole in the treatment of Helicobacter pylori

Comparison of two quadruple regimens of amoxicillin, bismuth, levofloxacin and pantoprazole versus amoxicillin, clarithromycin, bismuth, pantoprazole to eradicate Helicobacter pylori

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20220306054205N1

Enrollment

196

Registered

2022-04-18

Start date

2021-12-22

Completion date

Unknown

Last updated

2022-05-02

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Helicobacter pylori [H. pylori] as the cause of diseases classified elsewhere. Helicobacter pylori [H. pylori] as the cause of diseases classified elsewhere

Interventions

Intervention 1: Intervention group: Patients in the intervention group will use a four-drug regimen containing levofloxacin 500 daily, pantoprazole 20 twice daily, bismuth tablets every 12 hours and a

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: All patients tested positive for Helicobacter pylori after endoscopy

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
The primary outcome variable in this study is the eradication of Helicobacter pylori. To evaluate the eradication of Helicobacter pylori, urease breath test will be performed again 4 weeks after the end of treatment. If the test is negative, the treatment will be considered successful. Timepoint: 4 weeks after the end of treatment. Method of measurement: Urease breath test.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactAfshin Shafaghi

Rasht University of Medical Sciences

drafshinshafaghi@gmail.com+98 13 3332 8101

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026