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Effect of nanocurcumin and chlorhexidine mouthwash on level of prostaglandin E2

Evaluation of nanocurcumin and chlorhexidine mouthwash effect on the prostaglandin E2 biomarker concentration in gingival crevicular fluid of fixed orthodontic patients

Status
Recruiting
Phases
Phase 3
Study type
Interventional
Source
IRCT
Registry ID
IRCT20220223054108N2
Enrollment
88
Registered
2023-06-10
Start date
2023-06-20
Completion date
Unknown
Last updated
2023-06-26

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

teeth shifting. Encounter for other specified aftercare

Interventions

Intervention 1: Intervention group: In this group, patients are asked to mix 20 drops of nanocurcumin mouthwash with 10 cc of water and use for 30 seconds as a mouthwash twice a day for two weeks afte

Sponsors

Gorgan University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
All
Age
15 Years to 35 Years

Inclusion criteria

Inclusion criteria: Agreement to participation in the study 15 to 35 years old Passed at least 2 mounts after fixed orthodontics treatment Negative for hypersensitivity to Curcumin and/or chlorhexidine

Exclusion criteria

Exclusion criteria: The presence of any ulcer or intraoral infection Severe gingival inflammation or periodontal pocket Systemic disease Pregnant and lactating mothers Antibiotics usage in a month before the study Fluoride therapy in the last 6 months Tobacco usage Corticosteroids and NSAIDs usage

Design outcomes

Primary

MeasureTime frame
Prostaglandin E2 before and two weeks later in all studied groups. Timepoint: Measurement of prostaglandin E2 at the study's baseline (before starting treatment) and two weeks after consuming the prescribed mouthwashes for each group. Method of measurement: Enzyme-linked Immunosorbent Assay (ELISA test).

Secondary

MeasureTime frame
Patients' perception of taste in the group of patients using prescribed mouthwashes. Timepoint: The seventh day after using the prescribed mouthwashes. Method of measurement: Individually asking each of the participants about the taste of the prescribed mouthwash based on a questionnaire to check the quality of mouthwash.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactAliakbar Naghavialhosseini

Gorgan University of Medical Sciences

a.a.nagavi@gmail.com+98 17 3262 7823

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026