teeth shifting.
Conditions
Interventions
Intervention 1: Intervention group 1: In this group, patients are asked to mix 20 drops of nanocurcumin mouthwash with 10 cc of water and use for 30 seconds as a mouthwash twice a day for two weeks af
Sponsors
Gorgan University of Medical Sciences
Eligibility
Sex/Gender
All
Age
15 Years to 35 Years
Inclusion criteria
Inclusion criteria: Agreement to participation in the current study 15 to 35 years old Good periodontal health Systemically healthy Passed at least 2 mounts after fixed orthodontics treatment Negative for hypersensitivity to Curcumin and/or chlorhexidine.
Exclusion criteria
Exclusion criteria: Tobacco usage Antibiotics, Aspirin or non-steroidal anti-inflammatory drugs (NSAIDs) usage during the past one month Pregnant and lactating mothers
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Interleukin 1 & 6 before and two weeks later in the patients consuming curcumin mouthwash. Timepoint: Measurement of Interleukin1 & 6 in the study baseline (before treatment beginning) and 2 weeks after starting fixed orthodontic treatment. Method of measurement: Enzyme-linked Immunosorbent Assay (ELISA test).;Interleukin 1 & 6 before and two weeks later in the group of patients consuming chlorhexidine mouthwash. Timepoint: Measurement of Interleukin 1 & 6 in the study baseline (before treatment beginning) and 2 weeks after starting fixed orthodontic treatment. Method of measurement: Enzyme-linked Immunosorbent Assay (ELISA test).;Interleukin 1 & 6 before and two weeks after in the group consuming curcumin + chlorhexidine mouthwash. Timepoint: Measurement of Interleukin 1 & 6 in the study baseline (before treatment beginning) and 2 weeks after starting fixed orthodontic treatment. Method of measurement: Enzyme-linked Immunosorbent Assay (ELISA test).;Interleukin 1 & 6 before and two weeks after in the group of patients consuming normal saline mouthwash. Timepoint: Measurement of Interleukin 1 & 6 in the study baseline (before treatment beginning) and 2 weeks after starting fixed orthodontic treatment. Method of measurement: Enzyme-linked Immunosorbent Assay (ELISA test). | — |
Secondary
| Measure | Time frame |
|---|---|
| Comparison of differences in Interleukin 1 & 6 concentration before and two weeks later between two groups of patients using mouthwash containing curcumin and chlorhexidine. Timepoint: before treatment and 2 weeks after starting fixed orthodontic treatment. Method of measurement: ELISA (enzyme-linked immunosorbent assay).;Comparison of difference in Interleukin1 & 6 concentration before and two weeks later between two groups of patients using mouthwash containing curcumin and curcumin + chlorhexidine. Timepoint: before treatment and 2 weeks after starting fixed orthodontic treatment. Method of measurement: ELISA (enzyme-linked immunosorbent assay).;Comparison of differences in Interleukin1 & 6 concentration before and 2 weeks later between 2 groups of patients using mouthwash containing curcumin and normal saline. Timepoint: before treatment and 2 weeks after starting fixed orthodontic treatment. Method of measurement: ELISA (enzyme-linked immunosorbent assay).;Comparison of differences in Interleukin1 & 6 concentration before and 2 weeks later between 2 groups of patients using mouthwash containing chlorhexidine and curcumin+ chlorhexidine. Timepoint: before treatment and 2 weeks after starting fixed orthodontic treatment. Method of measurement: ELISA (enzyme-linked immunosorbent assay).;Comparison of differences in Interleukin1 & 6 concentration before and 2 weeks later between 2 groups of patients using mouthwash containing chlorhexidine and normal saline. Timepoint: before treatment and 2 weeks after starting fixed orthodontic treatment. Method of measurement: ELISA (enzyme-linked immunosorbent assay). | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactAliakbar Naghavialhosseini
Gorgan University of Medical Sciences
Outcome results
None listed