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Comparison of the effect of dexmedetomedine and remifentanil in reducing paranasal sinus surgery bleeding

Comparison of the effect of dexmedetomedine and remifentanil in reducing paranasal sinus surgery bleeding: a double-blind randomized clinical trial

Status
Active, not recruiting
Phases
Phase 3
Study type
Interventional
Source
IRCT
Registry ID
IRCT20220222054094N1
Enrollment
100
Registered
2022-02-27
Start date
2022-04-04
Completion date
Unknown
Last updated
2022-03-08

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Bleeding during paranasal sinus surgery.

Interventions

Intervention 1: Intervention group: After anesthesia induction in a similar plan, patients will receive dexmedetomidine (Precedex- Pfizer) at a dose of 0.2 µg / kg per hour as an infusion. Interventi

Sponsors

Sanandaj University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 45 Years

Inclusion criteria

Inclusion criteria: Age 18 to 45 years Patient in class 1 or 2 ASA physical status Patients who have referred for para-nasal sinus surgery, septoplasty and rhinoplasty

Exclusion criteria

Exclusion criteria: History of heart disease, hypertension, kidney, liver and lung and blood coagulation disorders History of mental health problems Patients receiving anti-hypertensive drugs Patients receiving NSAIDs Patients with a BMI greater than 30

Design outcomes

Primary

MeasureTime frame
Bleeding. Timepoint: Intervals of 15 minutes during surgery. Method of measurement: The amount of bleeding during the operation will be recorded based on the surgeon's comments and according to the quality of the surgical field, as well as the amount of bleeding based on the 5-point Likert scale in 15-minute intervals during the surgery.Score 1: Uncontrolled bleeding, Score 2: Severe bleeding, surgical field is distorted immediately after suction, Score 3: Moderate bleeding, frequent suction required, vision in the surgical field is moderate,Score 4: Minor bleeding, occasional suction required, vision in the surgical field is good,Score 5: No bleeding in the surgical field, almost bloodless. The amount of blood sucked in the suction bottle will also be measured (by calculating the amount of serum used for washing and reducing it from the total volume). Blood gases will also be weighed at the end of the operation using a heat scale.

Secondary

MeasureTime frame
Pain. Timepoint: Recovery period and every 2 hours to 6 hours after the recovery period. Method of measurement: Using the Visual Analogue Scale (VAS), which is a numerical scoring scale (zero painless to 10 highest pain), based on patient's statement.;Vital sign (Mean arterial pressure, heart rate and SPo2). Timepoint: Mean arterial pressure, heart rate and SPo2 will be recorded at 1 minute after intubation and then every 5 minutes to half an hour and then every 15 minutes until the end of the syrgery. It will also be measured at 15 minute intervals during the recovery period. Method of measurement: Patient bedside monitoring device(Non invasive blood pressure, Pulse oximetry ).;Sedation - Agitation. Timepoint: At Recovery period. Method of measurement: Using the 7-point sedation-Agitation Scale (Riker).

Countries

Iran (Islamic Republic of)

Contacts

Public ContactBehzad Ahsan

Sanandaj University of Medical Sciences

behzadahsan@gmail.com+98 87 3361 1231

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026