Effect of boost technique on toxicity of breast cancer radiotherapy

Comparison of the early skin toxicity and cosmetic outcome of concomitant boost radiotherapy with sequential boost radiotherapy after breast cancer conserving surgery

Status

Active, not recruiting

Phases

Phase 2

Study type

Interventional

Source

IRCT

Registry ID

IRCT20220221054089N1

Enrollment

100

Registered

2022-06-22

Start date

2018-08-23

Completion date

Unknown

Last updated

2022-06-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Breast cancer. Malignant neoplasms of breast

Interventions

Intervention 1: Intervention group: Concomitant boost with 10 Gray in 5 fraction, one session every weekend. Intervention 2: Control group: Sequential radiation boost, 10 Gray in 5 fraction at the end

Eligibility

Sex/Gender

Female

Age

18 Years to 75 Years

Inclusion criteria

Inclusion criteria: Women with pathologically proven breast cancer Age 18-75 Undergoing breast conserving surgery Early staged breast cancer (T1-3,N0-1)

Exclusion criteria

Exclusion criteria: Previous skin disease Previous breast radiation Previous cancer Positive margin on surgery Multifocal disease

Design outcomes

Primary

Measure	Time frame
Acute skin toxicity of breast radiotherapy. Timepoint: Weekly during radiotherapy. Method of measurement: Physical exam and grading the skin side effects via Common Terminology Criteria for Adverse Events version 4.;Cosmetic outcome. Timepoint: 6 and 12 months after radiotherapy. Method of measurement: Physical exam and scoring according to Harvard criteria.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactReyhane Bayani

Tehran University of Medical Sciences

bayani.reyhane@yahoo.com+98 21 6658 1619

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026