Severe traumatic brain injury. Diffuse traumatic brain injury
Conditions
Interventions
Intervention 1: Intervention group: severe traumatic brain injury patients receiving 20 mg/kg per day deferoxamine for 7 consecutive days and as a 24-hour intravenous infusion. Intervention 2: Control
it will be identical to the intervention drug in amount, shape, color, and packaging.
Sponsors
Shiraz University of Medical Sciences
Afa Chemi Pharmaceutical Company
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: Patients with severe traumatic brain injury Patients with pure traumatic brain injury: having a score of less and equal to 3 on the Brain Abbreviated Injury scale; and a score of less than 3 on the Extracranial Abbreviated Injury scale
Exclusion criteria
Exclusion criteria: Allergy to deferoxamine mesylate Serum creatinine more than 2 mg/dL Hemoglobin less than 7 g/L, or patients requiring transfusion therapy A Glasgow Coma Scale score of 3 or 4 with bilateral fixed and dilated pupils A known history of intracranial diseases A known history of thrombocytopenia (platelet count less than 50×109/L) Concurrent use of anti-coagulant or anti-platelet agents or history of coagulation disorders (international normalized ratio more than 1.4) Concurrent use of iron supplements or prochlorperazine Impaired hearing Pregnant or lactating women History of cardiopulmonary arrest and resuscitation Blood disorders (e.g. thalassemia, iron deficiency anemia) GFR less than 50 ml/min History of heart failure History of liver disease
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Glasgow Outcome Scale. Timepoint: At the time of discharge, three and six months after the intervention. Method of measurement: Glasgow Outcome Scale. | — |
Secondary
| Measure | Time frame |
|---|---|
| Duration of intensive care unit admission. Timepoint: From the admission date to discharge date from the intensive care unit. Method of measurement: Number of days.;Duration of hospital admission. Timepoint: From the admission date to discharge date from the hospital. Method of measurement: Number of days. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactZahra Eghlidos
Shiraz University of Medical Sciences
Outcome results
None listed