Beta thalassemia is genetic disorder which is caused by insertions and deletions in chromosome number 11. The disease is treated by blood transfusions which leads to iron over load and demand for chelation therapy. Some patients do not respond to this treatment and suffer from complications. Although treatment with hydroxyurea has leads to improved conditions by reducing transfusion demand, but some patients do not respond to this treatment. Hence, other treatment modalities which induce fetal h
Conditions
Interventions
Intervention 1: Intervention group: Patients diagnosed with beta thalassemia diagnosed according to clinical characteristics and hemoglobin electrophoresis were included in this study according to the
Sponsors
Sheikh Zayed Medical College/Hospital, Rahim Yar Khan
Eligibility
Sex/Gender
All
Age
2 Years to 15 Years
Inclusion criteria
Inclusion criteria: Beta thalassemia patients are diagnosed by clinical characteristics and by hemoglobin electrophoresis Age 2 years to 15 years Both Gender
Exclusion criteria
Exclusion criteria: Patients already undergoing treatment for induction of HbF Patients with liver, renal, cardiac, pulmonary, neurological deficits or history of thrombotic episodes Patients not giving consent to treatment
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Response to treatment. Timepoint: before intervention and after 6 months after intervention. Method of measurement: become transfusion free after treatment. | — |
Secondary
| Measure | Time frame |
|---|---|
| Number of transfusion and hemoglobin level. Timepoint: before intervention and after 6 months of intervention. Method of measurement: number of transfusion and hemoglobin level. | — |
Countries
Pakistan
Contacts
Public ContactProf. Dr. Muhammad Saleem Laghari
Department of Pediatrics (unit 2), Sheikh Zayed Medical College/Hospital, Rahim Yar Khan
Outcome results
None listed