acute post mastectomy pain and post operative inflammatory reaction. Other acute postprocedural pain
Conditions
Interventions
Intervention 1: control group: ultrasound guided unilateral erector spine plane block will be performed under complete aseptic condition after induction of general anesthesia directly and 15 min b
Sponsors
Mansoura university
Eligibility
Sex/Gender
Female
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: Female patients Aged 18–65 years, American Society of Anesthesiologists physical status I and II, Undergoing unilateral breast cancer surgery (modified radical mastectomy, breast conservational surgery, simple mastectomy and axillary clearance)
Exclusion criteria
Exclusion criteria: patient refusal, history of bronchial asthma spinal deformities, coagulation disorders, allergy to local anesthetics, history of opioid usage for chronic pain cognitive/psychiatric disorders infection at the injection site
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Time to rescue analgesia (opioid) in post operative period. Timepoint: time point measured from the end of surgery to request of analgesic. Method of measurement: visual analogue scale to measure pain assessment of pain if VAS is more than 3 patient will receive morphine 10 Mg intramuscular and reassess after 30 min for pain relieve . | — |
Secondary
| Measure | Time frame |
|---|---|
| Total opioid requirement. Timepoint: 24 hour post operative. Method of measurement: amount of drug prescribed amount of morphine consumption in Mg in 24 hour after the end of surgery.;Inflammatory mediators (interleukin 6,interlokin 10, and tumor necrotic factor. Timepoint: before intervention and 2hour post operative ,12 hour post operative , and 24 hour post operative. Method of measurement: lab kit to measure inflammatory mediators. | — |
Countries
Egypt
Contacts
Public ContactZenat Eldadamony Mohamed
Mansoura University Hospital
Outcome results
None listed