Comparison of the effects of Rivaroxaban and Apixaban with Heparin and Enoxaparin in patients undergoing gynecological oncological surgery.

Comparison of the effect of oral anticoagulants (Rivaroxaban and Apixaban) and injectable drugs (Heparin and Enoxaparin) to prevent bleeding in patients undergoing oncological gynecological surgeries

Status

Recruiting

Phases

Phase 2

Study type

Interventional

Source

IRCT

Registry ID

IRCT20220211053991N1

Enrollment

Registered

2023-06-12

Start date

2023-06-09

Completion date

Unknown

Last updated

2023-06-26

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Women's cancers including: endometrium, ovary, cervix, vulva. Malignant neoplasm of uterus, part unspecified

Interventions

Intervention 1: The first intervention group: the group receiving oral anticoagulant tablets apixaban and rivaroxaban with a dose of 2/5 mg twice a day after surgery, for 28 days, manufactured by Abur

Eligibility

Sex/Gender

Female

Age

18 Years to 70 Years

Inclusion criteria

Inclusion criteria: Age 18 to 70 years Obtaining informed consent Cancer disease

Exclusion criteria

Exclusion criteria: Liver failure Deep vein thrombosis (DVT) History of Gastrontestinal bleeding Pregnancy Taking other anticoagulants Breast feeding Post-transplant erythrocytosis (PTE) PTE disorders Kidney failure (glomerular filtration rate (GFR) less than 30)

Design outcomes

Primary

Measure	Time frame
Shortness of breath. Timepoint: Before and after surgery. Method of measurement: Examination.	—

Secondary

Measure	Time frame
Bleeding. Timepoint: Before and after surgery. Method of measurement: Examination.;Pain. Timepoint: Before and after surgery. Method of measurement: Examination.;Size of organ. Timepoint: Before and after surgery. Method of measurement: Examination.;Time to take the medicine. Timepoint: Before and after surgery. Method of measurement: Questionnaire.;Doppler ultrasound results. Timepoint: Before and after surgery. Method of measurement: ultrasound.;Swelling of the limbs. Timepoint: Before and after surgery. Method of measurement: Examination.	—

Measure

Time frame

Bleeding. Timepoint: Before and after surgery. Method of measurement: Examination.;Pain. Timepoint: Before and after surgery. Method of measurement: Examination.;Size of organ. Timepoint: Before and after surgery. Method of measurement: Examination.;Time to take the medicine. Timepoint: Before and after surgery. Method of measurement: Questionnaire.;Doppler ultrasound results. Timepoint: Before and after surgery. Method of measurement: ultrasound.;Swelling of the limbs. Timepoint: Before and after surgery. Method of measurement: Examination.

—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactAmine Arab

Iran University of Medical Sciences

amym.940225@gmail.com+98 21 8670 2504

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Mar 26, 2026