Investigating the effects of zinc supplementation in patients with blood infection

The effects of zinc supplementation in patients with sepsis: a clinical trial

Status

Active, not recruiting

Phases

Phase 2

Study type

Interventional

Source

IRCT

Registry ID

IRCT20220208053971N3

Enrollment

Registered

2023-06-10

Start date

2023-07-21

Completion date

Unknown

Last updated

2023-06-26

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

sepsis. Sepsis, unspecified organism

Interventions

Intervention 1: Intervention group: The patients in the intervention group will be given a zinc supplement containing 30 mg of Karen Zinc for 7 days. Intervention 2: Control group: In the control grou

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: Age over 18 years patient admitted to the intensive care unit patient with sepsis Patients under enteral nutrition (nasal, mouth, stomach)

Exclusion criteria

Exclusion criteria: Pregnancy or breastfeeding Body mass index over 35 (severe obesity) Human immunodeficiency virus (HIV) disease Patients at the time of transplantation Patients with orders not to receive any type of enteral nutrition Patients participating in other studies

Design outcomes

Primary

Measure	Time frame
Sequential Organ Failure Assessment. Timepoint: The effect of zinc supplementation on the SOFA score at the beginning of the study (before the intervention) and 1 week after the intervention in patients with sepsis in the intensive care unit. Method of measurement: SOFA questionnaire score.	—

Secondary

Measure	Time frame
28-day mortality. Timepoint: The effect of zinc supplementation on the 28-day mortality at the beginning of the study (before the intervention) and 1 week after the intervention in patients with sepsis in the intensive care unit. Method of measurement: questionnaire.;Inflammatory factors. Timepoint: The effect of zinc supplementation on the Inflammatory factors at the beginning of the study (before the intervention) and 1 week after the intervention in patients with sepsis in the intensive care unit. Method of measurement: blood test.;Nutritional status. Timepoint: The effect of zinc supplementation on the nutritional status at the beginning of the study (before the intervention) and 1 week after the intervention in patients with sepsis in the intensive care unit. Method of measurement: mNUTRIC questionnaire score.	—

Measure

Time frame

28-day mortality. Timepoint: The effect of zinc supplementation on the 28-day mortality at the beginning of the study (before the intervention) and 1 week after the intervention in patients with sepsis in the intensive care unit. Method of measurement: questionnaire.;Inflammatory factors. Timepoint: The effect of zinc supplementation on the Inflammatory factors at the beginning of the study (before the intervention) and 1 week after the intervention in patients with sepsis in the intensive care unit. Method of measurement: blood test.;Nutritional status. Timepoint: The effect of zinc supplementation on the nutritional status at the beginning of the study (before the intervention) and 1 week after the intervention in patients with sepsis in the intensive care unit. Method of measurement: mNUTRIC questionnaire score.

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactHamed Mohammadi

Tehran University of Medical Sciences

info_snsd@tums.ac.ir+98 21 8895 5975

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026