Effectiveness of muscle strengthening exercises on knee osteoarthritis

Effectiveness of muscle strengthening exercises on pain, physical function and morning stiffness of patients with osteoarthritis of knee : a randomized four-arm controlled trial

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

IRCT

Registry ID

IRCT20220206053950N2

Enrollment

Registered

2022-09-07

Start date

2016-02-25

Completion date

Unknown

Last updated

2022-11-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Osteoarthritis of knee. Osteoarthritis of knee

Interventions

Intervention 1: Intervention group: received home-based quadriceps strengthening exercises, regularly perform 3 sets of exercises per day, 10-15 repetitions, 5 days a week for 8 weeks. Intervention 2:

Eligibility

Sex/Gender

All

Age

40 Years to 70 Years

Inclusion criteria

Inclusion criteria: Patients with knee osteoarthritis (grades I-III in the Kellgren-Lawrence score) Patients aged 40-70 years Patients who had pain, morning stiffness of shorter than 30 minutes, or knee crepitus.

Exclusion criteria

Exclusion criteria: Concomitant involvement with musculoskeletal diseases other than knee osteoarthritis in one or both knees within the last 6 months A history of knee joint surgery Intra-articular injection of corticosteroids or hyaluronic acid in the knee joints within the past 30 days Non-steroidal anti-inflammatory drugs (NSAIDs) or glucosamine intake within the last 30 days Participation in the muscle-strengthening programs for the knee joint within the last 6 months

Design outcomes

Primary

Measure	Time frame
Score of knee pain on Visual Analogue Scale (VAS) score. Timepoint: At the beginning of the study (before the intervention) and 8 weeks after the initiation of the exercise therapy. Method of measurement: Visual Analogue Scale (VAS).;Score of knee physical function on the Western Ontario and McMaster (WOMAC) Index. Timepoint: At the beginning of the study (before the intervention) and 8 weeks after the initiation of the exercise therapy. Method of measurement: Western Ontario and McMaster (WOMAC) Index.;Score of knee morning stiffness on the Western Ontario and McMaster (WOMAC) Index. Timepoint: At the beginning of the study (before the intervention) and 8 weeks after the initiation of the exercise therapy. Method of measurement: Western Ontario and McMaster (WOMAC) Index.	—

Measure

Time frame

Score of knee pain on Visual Analogue Scale (VAS) score. Timepoint: At the beginning of the study (before the intervention) and 8 weeks after the initiation of the exercise therapy. Method of measurement: Visual Analogue Scale (VAS).;Score of knee physical function on the Western Ontario and McMaster (WOMAC) Index. Timepoint: At the beginning of the study (before the intervention) and 8 weeks after the initiation of the exercise therapy. Method of measurement: Western Ontario and McMaster (WOMAC) Index.;Score of knee morning stiffness on the Western Ontario and McMaster (WOMAC) Index. Timepoint: At the beginning of the study (before the intervention) and 8 weeks after the initiation of the exercise therapy. Method of measurement: Western Ontario and McMaster (WOMAC) Index.

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactMina Rostami

Zanjan University of Medical Sciences

mina.rostami1373@gmail.com+98 991 207 7996

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 12, 2026