substance induced psychosis. Other psychoactive substance dependence with psychoactive substance-induced psychotic disorder with hallucinations
Conditions
Interventions
Intervention 1: Intervention group: lactobacillus acidophilus capsule 10 exponent 8 unit daily for 8 weeks. Intervention 2: Control group: Starch placebo tablets exactly the same with probiotic capsul
Sponsors
Alborz university of medical sciences
Eligibility
Sex/Gender
All
Age
18 Years to 60 Years
Inclusion criteria
Inclusion criteria: Positive amphetamine and methamphetamine test Diagnosis of amphetamine use disorder based on DSM5 criteria after interview with psychiatrist Voluntary organization of the individual and his / her guardian to participate in the project Age: 18 to 60 years old IQ above 70 Not receiving to receive electroshock in the last two weeks Do not use other drugs (all opioids, morphine and methadone and marijuana are taken from the patient during the evaluation - testing of urinary toxic acid for amphetamine and methamphetamine) Lack of other psychiatric disorders such as schizophrenia Bipolar disorder Depression with psychosis
Exclusion criteria
Exclusion criteria: Prominent neurological or organic disease and cardiovascular disease and history of cardiac surgery or any cardiovascular procedure, clinical and laboratory examinations and review of family history and records Another diagnosis in Axis I based on DSM-V IQ less than 70 based on clinician clinical suspicion Abusing of other substances (except nicotine and caffeine) Taking oral antipsychotics in the past week or long-acting antipsychotics in the past month Receiving ECT in the last two weeks Women of childbearing age will not be accepted without adequate methods of contraception CHF and liver disease
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Amphetamine and methamphetamine-induced psychosis. Timepoint: At the beginning of this study, 4th and 8th weeks. Method of measurement: Brief Psychiatric Rating Scale.;The Beck Anxiety Inventory (BAI). Timepoint: At the beginning of this study, 4th and 8th weeks. Method of measurement: The Beck Anxiety Inventory (BAI).;Pittsburgh sleep quality index. Timepoint: At the beginning of this study, 4th and 8th weeks. Method of measurement: Pittsburgh Sleep Quality Index (PSQI). | — |
Secondary
| Measure | Time frame |
|---|---|
| Mild gastrointestinal discomfort. Timepoint: At the beginning of this study, 4th and 8th weeks. Method of measurement: Medical history. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactAtefe Zandifar
Alborz university of medical sciences
Outcome results
None listed