Evaluation of the effectiveness of low-dose ketamine (Sub dissociative) with dexmedetomidine in controlling pain in patients with limb trauma referred to emergency department

Evaluation of the efficacy of low-dose (sub dissociative) ketamine with dexmedetomidine, and its comparison with morphine in controlling pain in patients with limb trauma referred to emergency department of Sina hospital

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20220120053770N1

Enrollment

258

Registered

2022-02-12

Start date

2022-04-03

Completion date

Unknown

Last updated

2022-03-08

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Pain management of limb trauma in emergency department. Acute pain due to trauma

Interventions

Intervention 1: Intervention group: Intravenous ketamine with sub dissociative dose (0.3 mg / kg) with intravenous dexmedetomidine (1 mcg / kg). Intervention 2: Intervention group: Intravenous morphin

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: Adult patients (older than 18 years old) gave pain more than five points limb trauma pain obtaining the informed consent

Exclusion criteria

Exclusion criteria: Pain score =5 Pregnancy and post-partum women Altered mental status Allergy to ketamine or fentanyl Body weight = 46 kg or = 115 Unstable vital signs: BP= 90 mmHg or = 180 mmHg , PR=150 or =50 bits/min , RR=10 or =30 History of recent head or eye trauma History of Siesure History of elevated ICP Chronic pain Renal or hepatic failure Substance or alcohol abuse Documented psychiatric disorders Opium addiction Recent use of narcotic analgesics

Design outcomes

Primary

Measure	Time frame
Pain numerical rating scale. Timepoint: Intervals of 5, 10, 15, 30 minutes. Method of measurement: requires the patient to rate their pain (0–10) where 0 is no pain and 10 is the worst pain imaginable.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactAlireza Baratloo

Tehran University of Medical Sciences

arbaratloo@sina.tums.ac.ir+98 21 6634 8500

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026