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The Evaluation of effectiveness of betadine (Povidone-iodine) in one step and two step procedure in the treatment of patients with pleural effusion resistant to conventional treatments: a clinical trial

The Evaluation of effectiveness of betadine (Povidone-iodine) in one step and two step procedure in the treatment of patients with pleural effusion resistant to conventional treatments: a clinical trial

Status
Recruiting
Phases
Phase 2
Study type
Interventional
Source
IRCT
Registry ID
IRCT20220117053750N1
Enrollment
40
Registered
2022-02-28
Start date
2021-03-21
Completion date
Unknown
Last updated
2022-03-08

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Resistant pleural effusion.

Interventions

Intervention group:In this study, 20 patients received betadine in one step. 20 cc of 10% betadine is injected with 60 cc of normal saline and 5 cc of lidocaine and the catheter is removed and two wee

Sponsors

Kerman University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: In this study, patients with refractory pleural effusion with adhesions and a history of VATS and thoracoscopy are eligible for the study.

Exclusion criteria

Exclusion criteria: In contrast, patients who have a mass for whom catheterization is not possible will be excluded from the study process

Design outcomes

Primary

MeasureTime frame
Pleural effusion, reduction of pleural effusion. Timepoint: monthly. Method of measurement: Ultrasound of the pleural space.

Secondary

MeasureTime frame
Reduce dyspnea and cough. Timepoint: One week after pleural effusion injection. Method of measurement: In this study, a data collection form (Checklist) will be used to collect data. This form consists of 4 main parts. In the first part, the demographic characteristics of patients, including age and sex, as well as the type of pleural effusion disease, which is benign and malignant, are recorded. In the second part, the form of thyroid and kidney enzymes are recorded before and after the intervention. In the third part of the form, the length of the follow-up period and the final outcome of the treatment, which includes the success of the treatment and the failure of the treatment, are recorded. Side effects and patient complaints including chest pain, fever, shortness of breath, hypotension, vision loss, and air leakage are recorded at the end of the form.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactFaranak Salajegheh

Kerman University of Medical Sciences

f.salajegheh@kmu.ac.ir+98 34 3132 8325

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026