Intestinal adhesions [bands] with obstruction (postprocedural) (postinfection). Intestinal adhesions [bands] with obstruction (postprocedural) (postinfection)
Conditions
Interventions
Intervention 1: Control group: The control group will receive routine surgery process and placebo of Ziziphus jujuba, Ginseng, and famotidine will be given to them. Time, Form, and dose of placebo is
Sponsors
Mashhad University of Medical Sciences
Eligibility
Sex/Gender
All
Age
19 Years to 60 Years
Inclusion criteria
Inclusion criteria: Male or female aged 19 to 60 years Subjects candidate for two-stage planned operation Provide written documentation of informed consent to participate in the study.
Exclusion criteria
Exclusion criteria: Female patients that are pregnant or breastfeeding. Subjects suffering from intra-abdominal abscess Participants suffering from peritoneum bacterial infection Drug abuse Participants with Previous abdominal surgery history Subjects with type I-II Diabetes Patients suffering from metabolic syndrome Obese participants with BMI = 30
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Comparing frequency of adhesion bands in the presence and absence of the treatment. Timepoint: Between the 1st and the 2nd surgery. Method of measurement: Based on Zuhlke scoring system.;Comparing thickness of adhesion bands in the presence and absence of treatment. Timepoint: Between the 1st and the 2nd surgery. Method of measurement: Based on Zuhlke scoring system.;Comparing angiogenesis of adhesion bands in the presence and absence of treatment. Timepoint: Between the 1st and the 2nd surgery. Method of measurement: Based on Zuhlke scoring system.;Bowel obstruction due to adhesion band formation. Timepoint: Between the 1st and the 2nd surgery. Method of measurement: Macroscopic evaluation by surgeon. | — |
Secondary
| Measure | Time frame |
|---|---|
| Any side effect in the intervention group. Timepoint: Between the 1st and the 2nd surgery. Method of measurement: Analyzed by lab results and clinical outcomes.;Need to re-surgery. Timepoint: Within a year post-operation. Method of measurement: Clinical symptoms.;Rate of mortality post-surgery. Timepoint: Within a year post-operation. Method of measurement: Surgeon evaluation.;Presence of infection, abscess, and sepsis post-surgery. Timepoint: Within a year post-operation. Method of measurement: Analyzed by lab results and clinical outcomes. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactSeyed Mahdi Hassanian Mehr
Mashhad University of Medical Sciences
Outcome results
None listed