Proprioceptive Exercises with and without Topical Glucosamine Sulfate in Knee Osteoarthritis

Comparative analysis of Proprioceptive Exercises with and without Topical Glucosamine Sulfate on Pain and Functional Disability in Knee Osteoarthritis

Status

Active, not recruiting

Phases

Phase 2

Study type

Interventional

Source

IRCT

Registry ID

IRCT20220115053712N2

Enrollment

Registered

2022-02-28

Start date

2021-12-15

Completion date

Unknown

Last updated

2022-03-08

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Knee Osteoarthritis with grades 1, 2 and 3. Osteoarthritis of knee

Interventions

Intervention 1: Control group: Group A will be treated with only proprioceptive exercises. The proprioceptive exercises are Standing on 1 leg [eyes open and closed], Knee flexion and extension exercis

Eligibility

Sex/Gender

All

Age

45 Years to 70 Years

Inclusion criteria

Inclusion criteria: Age 4-70 years Cartilage degeneration Local biomechanical factors (e.g., obesity, joint deformity, muscle weakness) Nutritional factors Postmenopausal women Bilateral knee O.A with grade 1, 2 and 3 Both genders

Exclusion criteria

Exclusion criteria: Knee replacement Rheumatoid arthritis Steroidal injection in the past 2 months Neuropathy Tumor Knee fractures Neurological disorders (e.g., Alzheimer’s disease, Parkinson’s disease) OA grade 4

Design outcomes

Primary

Measure	Time frame
Pain. Timepoint: before and after treatment (6 weeks). Method of measurement: Numerical Pain Rating Scale (NPRS) and Western Ontario and McMaster Universities Arthritis Index (WOMAC).;Functional activities. Timepoint: before and after treatment (6 weeks). Method of measurement: Numerical Pain Rating Scale (NPRS) and Western Ontario and McMaster Universities Arthritis Index (WOMAC).	—

Secondary

Measure	Time frame
Stiffness. Timepoint: before and after treatment(6 weeks). Method of measurement: Numerical Pain Rating Scale (NPRS) and Western Ontario and McMaster Universities Arthritis Index (WOMAC).;Muscle tone strength. Timepoint: before and after treatment(6 weeks). Method of measurement: Numerical Pain Rating Scale (NPRS) and Western Ontario and McMaster Universities Arthritis Index (WOMAC).;Joint receptor function. Timepoint: before and after treatment(6 weeks). Method of measurement: Numerical Pain Rating Scale (NPRS) and Western Ontario and McMaster Universities Arthritis Index (WOMAC).	—

Measure

Time frame

Stiffness. Timepoint: before and after treatment(6 weeks). Method of measurement: Numerical Pain Rating Scale (NPRS) and Western Ontario and McMaster Universities Arthritis Index (WOMAC).;Muscle tone strength. Timepoint: before and after treatment(6 weeks). Method of measurement: Numerical Pain Rating Scale (NPRS) and Western Ontario and McMaster Universities Arthritis Index (WOMAC).;Joint receptor function. Timepoint: before and after treatment(6 weeks). Method of measurement: Numerical Pain Rating Scale (NPRS) and Western Ontario and McMaster Universities Arthritis Index (WOMAC).

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Countries

Pakistan

Contacts

Public ContactDr.Zahid Manzoor

Muhammad Institute of Medical and Allied Sciences, Multan

hifzaa630@gmail.com+92 309 7697428

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026