Alzheimer. Alzheimers disease
Conditions
Interventions
Intervention 1: Intervention group: Cyproterone acetate 50 mg every night for two weeks and increasing to 100 mg every night from the second to the sixth week. Intervention 2: Control group: One place
Sponsors
University of social welfare and rehabilitation sciences
Eligibility
Sex/Gender
All
Age
65 Years to No maximum
Inclusion criteria
Inclusion criteria: Having a diagnosis of Probable AD based on NIA-AA criteria At least two years have passed since the onset of the disease Having a diagnosis of agitated behaviors Cohen-Mansfield Agitation Inventory (CAMI) score of 45 and above Having a reliable companion who gives appropriate information about the patient Providing written consent to enter the study
Exclusion criteria
Exclusion criteria: Simultaneous treatment with other antipsychotics and antidepressants (if used before starting the study, these drugs should be stopped and the washout period should be considered appropriate) The criticality of the patient's behavioral state (thoughts of harming oneself or others) that does not allow randomization Any contraindications for prescribing cyproterone acetate
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Aggression score above 45 in Cohen-Mansfield Agitation Inventory (CMAI). Timepoint: Measuring aggression with the Cohen-Mansfield Agitation Inventory (CMAI) questionnaire at the beginning of the study (before the start of the intervention) and 4 and 6 weeks after the start of the study. Method of measurement: Aggression score above 45 in Cohen-Mansfield Agitation Inventory (CMAI). | — |
Countries
Central African Republic, Iran (Islamic Republic of)
Contacts
Public ContactNiloufar Nasrabadi
University of social welfare and rehabilitation sciences
Outcome results
None listed