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The effect of metformin and insulin in the prevention of preeclampsia

Evaluation of the effect of metformin and insulin combination therapy in comparison with the use of insulin alone in the prevention of preeclampsia in pregnant women with gestational diabetes

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
IRCT
Registry ID
IRCT20220107053652N1
Enrollment
150
Registered
2022-11-26
Start date
2022-07-23
Completion date
Unknown
Last updated
2023-02-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Pre-eclampsia. Pre-eclampsia

Interventions

Intervention 1: Intervention group: For the intervention group, oral metformin 500 milligram twice a day and insulin will be prescribed according to the patient's needs until the delivery or terminati

Sponsors

Esfahan University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
Female
Age
18 Years to 40 Years

Inclusion criteria

Inclusion criteria: Gestational diabetes Age of 18-40 years Single pregnancy Gestational age between 20-34 weeks Fasting glucose test more than 95 mg/dl or 2 hours postprandial glucose more than 120 mg

Exclusion criteria

Exclusion criteria: Having high blood pressure before pregnancy Previous history of any systemic disease (including cardiovascular, renal, hepatic, and autoimmune diseases) Addiction and drug abuse Obesity (Body mass index above 30) Overt diabetes Major neonatal malformations

Design outcomes

Primary

MeasureTime frame
Blood Pressure. Timepoint: Once every two weeks. Method of measurement: Using a sphygmomanometer.

Secondary

MeasureTime frame
Weight. Timepoint: During the period of pregnancy. Method of measurement: Balance.;Fasting blood sugar. Timepoint: The periods during pregnancy. Method of measurement: Using a glucometer.;Blood sugar after eating. Timepoint: The periods during pregnancy. Method of measurement: Using a glucometer.;High proteins in the urine. Timepoint: The periods during pregnancy. Method of measurement: Using urine test.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactDr. Farinaz Farhbod

Esfahan University of Medical Sciences

Farinaz.farahbod@gmail.com+98 31 3236 2191

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026