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Effect of adding long-acting GnRH agonist plus Letrozole to frozen embryo transfer cycles

Effect of adding long-acting GnRH agonist plus Letrozole to endometrial preparation method with Estradiol on pregnancy outcome in frozen embryo transfer cycles among women with recurrent implantation failure: A clinical trial

Status
Recruiting
Phases
Phase 3
Study type
Interventional
Source
IRCT
Registry ID
IRCT20220104053629N1
Enrollment
64
Registered
2022-02-13
Start date
2022-02-19
Completion date
Unknown
Last updated
2022-03-08

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Female infertility. Female infertility

Interventions

Intervention 1: Control group: This group just receive 6 mg of Estradiol valerate daily from the second day of the menstrual cycle. Transvaginal sonography is performed on day 13 of the menstrual cycl

Sponsors

Yazd University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
Female
Age
18 Years to 42 Years

Inclusion criteria

Inclusion criteria: 18 to 42 years old infertile women The history of at least two implantation failure of good quality embryos (A and B) Frozen thawed embryo transfer cycle Candidate for embryo transfer with A and B grade

Exclusion criteria

Exclusion criteria: Severe male factor or sperm retrieval except ejaculation Endometriosis in previous sonography or laparascopy Severe adenomiosis in sonography History of myoma surgery or any interfering myoma with implantatio History of implantation failure because of thin endometrium

Design outcomes

Primary

MeasureTime frame
Rate of chemical pregnancy. Timepoint: 2 weeks after embryo transfer. Method of measurement: pregnancy blood test.

Secondary

MeasureTime frame
Rate of clinical pregnancy. Timepoint: 4 weeks after embryo transfer. Method of measurement: Seeing gestational sac in sonography.;Rate of chemical abortion. Timepoint: 4 weeks after embryo transfer. Method of measurement: Positive pregnancy blood test without gestational sac.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactRazieh Dehghani Firoozabadi

Yazd University of Medical Sciences

Firouzabadirazieh@gmail.com+98 35 3824 7085

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026