Evaluation of the effect of topical aminophylline in hyposmic and anosmic patients

Evaluation of the effect of topical aminophylline in hyposmic and anosmic patients referred to the ENT clinic in Firoozgar hospital in 2020-2021

Status

Recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20220104053625N1

Enrollment

Registered

2022-01-10

Start date

2022-02-07

Completion date

Unknown

Last updated

2022-02-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Patient with Post viral hyposmia. Anosmia

Interventions

Intervention 1: Intervention group: Aminophylline drops (using the contents of the vial aminophylline in the form of nasal drops, 250 micrograms daily) ,8 drops were used daily on each side of the no

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: patients older than 18 years diagnosis of post viral hyposmia or anosmia, the course of olfactory dysfunction was > 6 months signing the written informed consent to participate study

Exclusion criteria

Exclusion criteria: lack of proper compliance to the prescribed drugs history of nasal or skull base surgeries, history of nasal polyps, history of facial or nasal trauma allergies to aminophylline or theophylline consumption of other drugs.

Design outcomes

Primary

Measure	Time frame
Patients' olfactory level. Timepoint: Before the intervention and three months after taking the drops. Method of measurement: SIT (smell identification test).	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactPardis Rahimi

Iran University of Medical Sciences

Pardiss.rahimi@gmail.com+98 21 6637 2369

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026