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Centella asiatica extract on the prevention of radiation-induced dermatitis in breast cancer patients

Comparison of the effectiveness of administration of Centella asiatica extract in comparison with placebo on the prevention of radiation-induced dermatitis in breast cancer patients

Status
Active, not recruiting
Phases
Phase 2
Study type
Interventional
Source
IRCT
Registry ID
IRCT20211231053576N1
Enrollment
78
Registered
2022-01-18
Start date
2022-02-20
Completion date
Unknown
Last updated
2022-02-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Breast cancer. Malignant neoplasm of breast

Interventions

Intervention 1: Intervention group: During radiation therapy for breast cancer patients, treatment with Centella Asiatica extract (made by Nature Healing Songs Company, Tehran, Iran) will be done. Pat

Sponsors

Shiraz University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
Female
Age
18 Years to 65 Years

Inclusion criteria

Inclusion criteria: Age between 18-65 The Karnofsky performance scale more and equal 70 Newly diagnosed breast cancer patients Patients underwent breast conserving surgery A tumor size more than 5 centimeter in patients underwent mastectomy Regional lymph-node involvement in patients underwent mastectomy Conventional radiotherapy regimen

Exclusion criteria

Exclusion criteria: Not giving consent to participate Pregnancy History of breast and chest radiation therapy History of connective tissue disease such as scleroderma or systemic lupus Distant metastasis at the presentation

Design outcomes

Primary

MeasureTime frame
Dermatitis. Timepoint: Weekly during the intervention. Method of measurement: Physical examination.

Secondary

MeasureTime frame
Radiotherapy leave. Timepoint: Weekly during the intervention. Method of measurement: History taking.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactZiba Afshari Aghajari

Shiraz University of Medical Sciences

ziba.afshar68@gmail.com+98 71 3647 4332

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026