Overweight and obesity. Overweight and obesity
Conditions
Interventions
Intervention 1: Intervention group: This group will receive an animal-based protein test meal. The test meal will provide 25% of the calculated total energy requirements and will consist of 30% protei
Sponsors
Mashhad University of Medical Sciences
Eligibility
Sex/Gender
Male
Age
18 Years to 60 Years
Inclusion criteria
Inclusion criteria: Men aged between 18 and 60 years old 35>BMI >25 Apparently healthy men Provision of written informed consent
Exclusion criteria
Exclusion criteria: Professional athletes Current smoking habits History of cardiovascular diseases, hypertension, diabetes mellitus, hyperlipidemia, neurological and/or neuropsychological disorders, and renal disorders Using medications or supplements affecting energy and protein metabolism (e.g., thyroid drugs, Supplements containing L-carnitine, ephedrine, caffeine, and antidepressant drugs) Using protein supplements Using weight loss or weight gain supplements Using medications or supplements affecting appetite History of more than 10% change in body weight within the past 6 months Skipping breakfast regularly (having breakfast less than 5 times a week) Having dietary restrictions Trypanophobia (extreme fear of injections, hypodermic needles) or haemophobia (extreme fear of blood)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Respiratory quotient. Timepoint: In the fasting state and during 5 hours after test meal (1,3, and 5 hours after test meal). Method of measurement: Indirect calorimetry (Metalyzer 3B).;Resting energy expenditure. Timepoint: In the fasting state and during 5 hours after test meal (1,3, and 5 hours after test meal). Method of measurement: Indirect calorimetry (Metalyzer 3B).;Diet induced thermogenesis. Timepoint: In the fasting state and during 5 hours after test meal (1,3, and 5 hours after test meal). Method of measurement: Indirect calorimetry (Metalyzer 3B).;Pulse wave velocity. Timepoint: In the fasting state and during 5.5 hours after test meal (0.5, 1.5, 3.5 , and 5.5 hours after test meal). Method of measurement: Tonometry.;Pulse wave analysis. Timepoint: In the fasting state and during 5.5 hours after test meal (0.5, 1.5, 3.5 , and 5.5 hours after test meal). Method of measurement: Sphygmocor device.;Appetite response. Timepoint: In the fasting state and during 5 hours after test meal (every 1 hour). Method of measurement: Visual analogue scales (VAS). | — |
Secondary
| Measure | Time frame |
|---|---|
| Blood glucose level. Timepoint: In the fasting state and during 5.5 hours after test meal (0.5, 1.5, 3.5, and 5.5 hours after test meal). Method of measurement: Enzymatic colorimetric method.;Serum insulin level. Timepoint: In the fasting state and during 5.5 hours after test meal (0.5, 1.5, 3.5, and 5.5 hours after test meal). Method of measurement: Elisa method.;Triglyceride level. Timepoint: In the fasting state and during 5.5 hours after test meal (0.5, 1.5, 3.5, and 5.5 hours after test meal). Method of measurement: Enzymatic method.;Total cholesterol level. Timepoint: In the fasting state and during 5.5 hours after test meal (0.5, 1.5, 3.5, and 5.5 hours after test meal). Method of measurement: Enzymatic method.;Low Density Lipoprotein- cholesterol level. Timepoint: In the fasting state and during 5.5 hours after test meal (0.5, 1.5, 3.5, and 5.5 hours after test meal). Method of measurement: Enzymatic method.;High Density Lipoprotein-Cholesterol (HDL-C) level. Timepoint: In the fasting state and during 5.5 hours after test meal (0.5, 1.5, 3.5, and 5.5 hours after test meal). Method of measurement: Enzymatic method.;Serum free fatty acids. Timepoint: In the fasting state and during 5.5 hours after test meal (0.5, 1.5, 3.5, and 5.5 hours after test meal). Method of measurement: Enzymatic Colorimetric. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactZahra Dehnavi
Mashhad University of Medical Sciences
Outcome results
None listed