Determining the effectiveness of Remote Ischemic Postconditioning in the treatment of patients with ischemic stroke

Determining the effectiveness of Remote Ischemic Postconditioning in the treatment of patients with ischemic stroke - Randomized Clinical trial

Status

Recruiting

Phases

Unknown

Study type

Interventional

Source

IRCT

Registry ID

IRCT20211226053525N1

Enrollment

160

Registered

2022-01-22

Start date

2022-02-04

Completion date

Unknown

Last updated

2022-02-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Ischemic stroke. Other specified cerebrovascular diseases

Interventions

Intervention 1: Intervention group: Remote Ischemic Postconditioning (RIPC) procedure will be performed on the first day of hospitalization under the following protocol: Sphygmomanometer will be attac

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: No dependence on care before the stroke and MRS score <= 2 Presence of a CT SCAN or MRI indicating the occurrence of the stroke National Institutes of Health Stroke Scale (NIHSS) score between 5 and 15 at the beginning Less than 24 hours interval between the occurrence of the stroke and the onset of RIPC Signed informed consent by patients or companions

Exclusion criteria

Exclusion criteria: Cerebral diseases such as intracranial aneurysm, vascular malformation and dementia Previous brain surgery, hemorrhagic stroke or ischemic stroke in the last 3 months Pregnancy Severe comorbidity (incurable disease, advanced cancer with low life expectancy, renal and hepatic failure, rheumatic diseases) Peripheral vascular disease, severe liver disease, history of chronic lung disease, liver disease, kidney disease, doctor's order

Design outcomes

Primary

Measure	Time frame
National Institutes of Health Stroke Scale (NIHSS). Timepoint: On admission, at discharge and on day 90. Method of measurement: Calculation of score through questionnaire and based on patient examination.;Modified Rankin Scale (MRS). Timepoint: On admission, at discharge and on day 90. Method of measurement: Calculation of score through based on patient examination and scale.;Clinical outcome. Timepoint: at discharge. Method of measurement: Based on patients' files.;Hospital stay. Timepoint: at discharge. Method of measurement: Based on patients' files.	—

Measure

Time frame

National Institutes of Health Stroke Scale (NIHSS). Timepoint: On admission, at discharge and on day 90. Method of measurement: Calculation of score through questionnaire and based on patient examination.;Modified Rankin Scale (MRS). Timepoint: On admission, at discharge and on day 90. Method of measurement: Calculation of score through based on patient examination and scale.;Clinical outcome. Timepoint: at discharge. Method of measurement: Based on patients' files.;Hospital stay. Timepoint: at discharge. Method of measurement: Based on patients' files.

—

Secondary

Measure	Time frame
Blood sugar. Timepoint: On admission, at discharge and on day 90. Method of measurement: Based on patient test results.;Blood pressure. Timepoint: On admission, at discharge and on day 90. Method of measurement: based on examination.;Blood indices: Cell blood count (CBC), Prothrombin time (PT), The international normalized ratio (INR), Partial Thromboplastin Time (PTT). Timepoint: On admission, at discharge and on day 90. Method of measurement: Based on patient test results.;Creatine kinase total. Timepoint: On admission, at discharge and on day 90. Method of measurement: Based on patient test results.;Creatinine (Cr). Timepoint: On admission, at discharge and on day 90. Method of measurement: Based on patient test results.;Liver enzymes: Aspartate aminotransferase (AST) , Alanine transaminase (ALT). Timepoint: On admission, at discharge and on day 90. Method of measurement: Based on patient test results.	—

Measure

Time frame

Blood sugar. Timepoint: On admission, at discharge and on day 90. Method of measurement: Based on patient test results.;Blood pressure. Timepoint: On admission, at discharge and on day 90. Method of measurement: based on examination.;Blood indices: Cell blood count (CBC), Prothrombin time (PT), The international normalized ratio (INR), Partial Thromboplastin Time (PTT). Timepoint: On admission, at discharge and on day 90. Method of measurement: Based on patient test results.;Creatine kinase total. Timepoint: On admission, at discharge and on day 90. Method of measurement: Based on patient test results.;Creatinine (Cr). Timepoint: On admission, at discharge and on day 90. Method of measurement: Based on patient test results.;Liver enzymes: Aspartate aminotransferase (AST) , Alanine transaminase (ALT). Timepoint: On admission, at discharge and on day 90. Method of measurement: Based on patient test results.

—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactDr. Mozafar hosseininezhad

Rasht University of Medical Sciences

hosseininezhadm@gmail.com+98 13 3332 5783

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026