Title : Acellular dermal matrix loaded with zinc oxide nanoparticles as a new membrane in extraction socket preservation technique: a clinical and CBCT study

Acellular dermal matrix loaded with zinc oxide nanoparticles as a new membrane in extraction socket preservation technique: a clinical and CBCT study

Status

Recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20211224053505N1

Enrollment

Registered

2022-02-19

Start date

2022-02-14

Completion date

Unknown

Last updated

2022-03-08

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Extraction Socket preservation. Periodontal disease, unspecified

Interventions

Intervention 1: Intervention group: test group: ZnO Nano Particles loaded Acellular Dermal Matrix, Human skin specimen will be obtained from abdominal plastic surgeries performed in Department of Plas

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: Age = ?? years Adequate restorative space for implant-retained restoration Presence of all ? walls of the socket At least ?? mm alveolar bone height without impingement on the maxillary sinus or mandibular canal Presence of one mesial and one distal tooth.

Exclusion criteria

Exclusion criteria: Presence of periodontal disease smoking History of systemic diseases that contraindicate oral surgery Long-term non-steroidal anti-inflammatory drug therapy Bisphosphonate therapy Pregnancy or lactation Absence of vestibular or lingual socket wall

Design outcomes

Primary

Measure	Time frame
Clinical evaluation: After tooth extraction: 1.Vestibular bone thickness (VBT), is measured with a surgical caliper ? mm below the residual alveolar bone margin to the nearest ?.? mm. Timepoint: At the baseline before performing the extraction socket preservation technique and then after 4 months. Method of measurement: by caliper and periodontal probe.;Clinical evaluation: After tooth extraction: Ridge width (RW) is measured at the midfacial level of the buccal bone plate using a surgical caliper ? mm from the crest of the ridge to the nearest ?.? mm. Timepoint: At the baseline before performing the extraction socket preservation technique and then after 4 months. Method of measurement: by caliper and periodontal probe.;Clinical evaluation: After tooth extraction: The heights of the vestibular and lingual crest (HVC-HLC) is measured by using a periodontal probe to connect the midfacial CEJs of the adjacent teeth, then measuring the vertical distance from that reference line to the crest of bone on the midfacial and midlingual sides. Timepoint: At the baseline before performing the extraction socket preservation technique and then after 4 months. Method of measurement: by caliper and periodontal probe.;Radiographic evaluation: Linear measurements are made on the CBCT images: The horizontal ridge width is calculated at three horizontal lines (? mm, ? mm, and ? mm apical to the most coronal aspect of the crest) perpendicular to a vertical reference line drawn in the center of the extraction socket and crossing its most apical point at baseline (HW-?, HW-?, HW-?). Timepoint: At the baseline before performing the extraction socket preservation technique and then after 4 months. Method of measurement: by Cone Beam Computed Tomography (CBCT).;Radiographic evaluation: Linear measurements are made on the CBCT images: The thickness of the buccal bone plate is measured only at baseline on the same levels apical to the lingual bone crest (BBP-?, BBP-?, BBP-?). Timepoint: At th	—

Measure

Time frame

Clinical evaluation: After tooth extraction: 1.Vestibular bone thickness (VBT), is measured with a surgical caliper ? mm below the residual alveolar bone margin to the nearest ?.? mm. Timepoint: At the baseline before performing the extraction socket preservation technique and then after 4 months. Method of measurement: by caliper and periodontal probe.;Clinical evaluation: After tooth extraction: Ridge width (RW) is measured at the midfacial level of the buccal bone plate using a surgical caliper ? mm from the crest of the ridge to the nearest ?.? mm. Timepoint: At the baseline before performing the extraction socket preservation technique and then after 4 months. Method of measurement: by caliper and periodontal probe.;Clinical evaluation: After tooth extraction: The heights of the vestibular and lingual crest (HVC-HLC) is measured by using a periodontal probe to connect the midfacial CEJs of the adjacent teeth, then measuring the vertical distance from that reference line to the crest of bone on the midfacial and midlingual sides. Timepoint: At the baseline before performing the extraction socket preservation technique and then after 4 months. Method of measurement: by caliper and periodontal probe.;Radiographic evaluation: Linear measurements are made on the CBCT images: The horizontal ridge width is calculated at three horizontal lines (? mm, ? mm, and ? mm apical to the most coronal aspect of the crest) perpendicular to a vertical reference line drawn in the center of the extraction socket and crossing its most apical point at baseline (HW-?, HW-?, HW-?). Timepoint: At the baseline before performing the extraction socket preservation technique and then after 4 months. Method of measurement: by Cone Beam Computed Tomography (CBCT).;Radiographic evaluation: Linear measurements are made on the CBCT images: The thickness of the buccal bone plate is measured only at baseline on the same levels apical to the lingual bone crest (BBP-?, BBP-?, BBP-?). Timepoint: At th

—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactFarin Kiany Yazdi

Shiraz University of Medical Sciences

farinkiany@yahoo.com+98 71 3626 3193

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026