Effect of Glucose-Insulin-Potassium in Creatine Phosphokinase (CPK)

Evaluation of the effect of Glucose-Insulin-Potassium to decrease level of Creatine Phosphokinase (CPK) in multiple trauma patients

Status

Recruiting

Phases

Unknown

Study type

Interventional

Source

IRCT

Registry ID

IRCT20211220053468N1

Enrollment

Registered

2022-06-12

Start date

2022-06-22

Completion date

Unknown

Last updated

2022-06-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Trauma, Rhabdomyolysis.

Interventions

Intervention 1: Intervention group: In this group, on the first and second day of the study, the pre-prepared solution, including a 50 ml vial of 50% Dextrose plus 10 units of regular Insulin plus 10

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: Trauma patient More than 18 years old Satisfaction with participation in the study CPK>3000 Urine output = 0.5 cc/kg/hour

Exclusion criteria

Exclusion criteria: Absence of Angina, history of Malignant Hyperthermia, history of Myocarditis, Muscular Dystrophy, Rheumatoid Arthritis, Liver disease, Connective tissue disease, Heart failure Absence of Shock( BP more than 90 mmHg) Absence of Hypo- or Hyperglycemia( BS 100-250) Absence of Hypo- or Hyperkalemia( K 2.8 - 5)

Design outcomes

Primary

Measure	Time frame
Level of blood creatine phosphokinase (CPK). Timepoint: Creatine phosphokinase (CPK) blood levels are measured on the first day of the study (before the intervention) and on the first and second days after. Method of measurement: Creatine phosphokinase levels in blood samples are measured in a hospital laboratory.	—

Secondary

Measure	Time frame
Blood creatinine level. Timepoint: Creatinine blood levels are measured on the first day of the study (before the intervention) and on the first and second days after. Method of measurement: Blood samples are measured in hospital laboratory.;Blood potassium. Timepoint: Blood potassium levels are measured on the first day of the study (before the intervention) and on the first and second days after. Method of measurement: Blood samples are measured in hospital laboratory.;Blood sugar. Timepoint: Blood sugar levels are measured on the first day of the study (before the intervention) and on the first and second days after. Method of measurement: Blood samples are measured in hospital laboratory.	—

Measure

Time frame

Blood creatinine level. Timepoint: Creatinine blood levels are measured on the first day of the study (before the intervention) and on the first and second days after. Method of measurement: Blood samples are measured in hospital laboratory.;Blood potassium. Timepoint: Blood potassium levels are measured on the first day of the study (before the intervention) and on the first and second days after. Method of measurement: Blood samples are measured in hospital laboratory.;Blood sugar. Timepoint: Blood sugar levels are measured on the first day of the study (before the intervention) and on the first and second days after. Method of measurement: Blood samples are measured in hospital laboratory.

—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactReza Beheshti Monfared

Shahid Beheshti University of Medical Sciences

r_beheshti_m@yahoo.com+98 21 7343 0000

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026