The Effectiveness of Comorbid Transcranial Direct Current Stimulation and Upper Limb Occupational Therapy in People with Multiple Sclerosis

The Effectiveness of Comorbid Transcranial Direct Current Stimulation and Upper Limb Occupational Therapy on Occupational Performance and Fine Motor Movement in People with Multiple Sclerosis: A Randomized Controlled Trial

Status

Recruiting

Phases

Unknown

Study type

Interventional

Source

IRCT

Registry ID

IRCT20211220053459N3

Enrollment

Registered

2025-09-26

Start date

2025-09-23

Completion date

Unknown

Last updated

2025-10-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Multiple sclerosis. Multiple sclerosis

Interventions

Intervention 1: Intervention group: In this study, the therapeutic intervention will consist of anodal transcranial direct current stimulation (tDCS) combined with specialized upper limb occupational

Eligibility

Sex/Gender

All

Age

18 Years to 65 Years

Inclusion criteria

Inclusion criteria: Definitive diagnosis of multiple sclerosis according to the McDonald criteria Age between 18 and 65 years Right-handedness Score between 2 and 5 on the Expanded Disability Status Scale (EDSS) No similar treatments in the past three months Presence of impairment in fine hand movements Score higher than 22 on the Mini-Memory Cognitive Assessment (MMSE)

Exclusion criteria

Exclusion criteria: Presence of other neurological diseases or severe cognitive impairment Pregnancy Having metal devices (such as pacemakers) that interfere with TDCS Uncooperative in performing exercises

Design outcomes

Primary

Measure	Time frame
Occupational performance. Timepoint: Before, after and one month after the intervention. Method of measurement: Canadian Occupational Performance Measurement.;Hand Function. Timepoint: Before, after and one month after the intervention. Method of measurement: The Jebsen-Taylor Manual Function Test.;Hand skill. Timepoint: Before, after and one month after the intervention. Method of measurement: Nine-hole peg test.	—

Measure

Time frame

Occupational performance. Timepoint: Before, after and one month after the intervention. Method of measurement: Canadian Occupational Performance Measurement.;Hand Function. Timepoint: Before, after and one month after the intervention. Method of measurement: The Jebsen-Taylor Manual Function Test.;Hand skill. Timepoint: Before, after and one month after the intervention. Method of measurement: Nine-hole peg test.

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactFatemeh Motaharinezhad

Semnan University of Medical Sciences

fatemeh.motahari@semums.ac.ir+98 912 453 1870

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026