Effect of cyproheptadine on headache and hypotension after spinal anesthesia

Preventive effect of cyproheptadine in preventing headache and hypotension in spinal anesthesia in patients undergoing spinal anesthesia

Status

Recruiting

Phases

Phase 2

Study type

Interventional

Source

IRCT

Registry ID

IRCT20211218053439N1

Enrollment

Registered

2022-02-22

Start date

2022-02-20

Completion date

Unknown

Last updated

2022-03-08

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Spinal anesthesia induced headache and hypotension. -

Interventions

Intervention 1: Intervention group: Receiving cyproheptadine tablets with a dose of 4 mg and single dose orally. Intervention 2: Control group: receiving single-dose ciproheptadine placebo tablets ora

Eligibility

Sex/Gender

All

Age

20 Years to 70 Years

Inclusion criteria

Inclusion criteria: Surgery under spinal anesthesia Elective surgery American Society of Anesthesiologists(ASA) class I Age between 20 and 70 years

Exclusion criteria

Exclusion criteria: Reluctance to participate in the study Having any underlying disease Emergency surgery

Design outcomes

Primary

Measure	Time frame
Spinal anesthesia-induced headache. Timepoint: Evaluation of headache at the beginning of the study (before surgery) and 24 and 48 hours after surgery. Method of measurement: Through questionnaire.;Spinal anesthesia-induced hypotension. Timepoint: Measurement of blood pressure at the beginning of the study (before surgery) and 24 and 48 hours after surgery. Method of measurement: Blood pressure monitoring.	—

Measure

Time frame

Spinal anesthesia-induced headache. Timepoint: Evaluation of headache at the beginning of the study (before surgery) and 24 and 48 hours after surgery. Method of measurement: Through questionnaire.;Spinal anesthesia-induced hypotension. Timepoint: Measurement of blood pressure at the beginning of the study (before surgery) and 24 and 48 hours after surgery. Method of measurement: Blood pressure monitoring.

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactZahra Farhadi

Islamic Azad University

sabafarhadi9675@gmail.com+98 23 3220 1378

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026