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Comparison of the effect of indomethacin as a non-steroidal anti-inflammatory drug and acetaminophen for postoperative pain in patients undergoing cross-linking (cxl) surgery

Comparison of the effect of indomethacin as a non-steroidal anti-inflammatory drug and acetaminophen for postoperative pain in patients undergoing cross-linking (cxl) surgery

Status
Recruiting
Phases
Unknown
Study type
Interventional
Source
IRCT
Registry ID
IRCT20211215053417N1
Enrollment
50
Registered
2021-12-20
Start date
2021-12-25
Completion date
Unknown
Last updated
2022-01-11

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

cross-linking (cxl) surgery.

Interventions

Intervention 1: Intervention group: One hour before surgery, they receive a single dose of 75 mg slow-release indomethacin tablets made in Iran and Aria Pharmaceutical Company. Intervention 2: Control

Sponsors

Yazd University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
All
Age
16 Years to 35 Years

Inclusion criteria

Inclusion criteria: Male and female patients between 16 and 35 years of age included unlikely consecutive sampling of significant keratoconus with readings greater than 47 d and central corneal thickness greater than 400um.

Exclusion criteria

Exclusion criteria: patients with a history of eye surgery, acute corneal hydrops, dense corneal ectasia, corneal opacity, any history of NSAID allergies, or the use of topical / systemic anti-inflammatory drugs are excluded from the study within two weeks prior to surgery. Also, patients with a BMI of less than 18.5 and more than 30 are excluded from the study due to changes in the use of analgesic doses for pharmacological effects.

Design outcomes

Primary

MeasureTime frame
Visual Pain Scale (VAS) Score. Timepoint: Visual Pain Scale (VAS) questionnaire is determined at 4 hours after surgery and the number of analgesics used during 24 hours after surgery. Method of measurement: Visual Pain Scale (VAS).

Countries

Iran (Islamic Republic of)

Contacts

Public ContactFaezeh Mazidi Sharafabadi

Yazd University of Medical Sciences

f.mazidi@stu.ssu.ac.ir+98 35 3183 3220

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026