Condition 1: Depression. Condition 2: Suicide idea. Condition 3: Opioids abuse. Major depressive disorder, single episode Other symptoms and signs involving emotional state Mental and behavioural disorders due to use of opioids
Conditions
Interventions
Intervention 1: Intervention-control group A: Patients in this group receive infusion ketamine as an intervention and oral placebo tablet as control. . Ketamine hydrochloride will receive at a dose o
Sponsors
Shiraz University of Medical Sciences
Eligibility
Sex/Gender
All
Age
18 Years to 60 Years
Inclusion criteria
Inclusion criteria: Patients admitted to Ebn Sina Hospital in Shiraz with a diagnosis of major depression or depression induced by opioid use Age between 18 and 60 years Opium user according to DSM5 criteria
Exclusion criteria
Exclusion criteria: Having a major comorbid psychiatric illness such as psychosis or bipolar spectrum Having major physical illnesses such as cardiovascular disease - Uncontrolled blood pressure - Uncontrolled diabetes - Uncontrolled thyroid disease
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Depression. Timepoint: Before the intervention, the day of the intervention, 24 hours after the intervention, one week after the intervention. Method of measurement: Beck Depression Inventory. | — |
Secondary
| Measure | Time frame |
|---|---|
| Anxiety. Timepoint: Before the intervention, the day of the intervention, 24 hours after the intervention, one week after the intervention. Method of measurement: Hamilton Anxiety Questionnaire.;Suicide idea. Timepoint: Before the intervention, the day of the intervention, 24 hours after the intervention, one week after the intervention. Method of measurement: Beck suicide questionnaire. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactDr. Amir Bazrafshan
Shiraz University of Medical Sciences
Outcome results
None listed