Effects of Zeolive on hepatotoxicity

Evaluation of the protective effects of Zeolive on hepatotoxicity of acetaminophen poisoning

Status

Active, not recruiting

Phases

Phase 1

Study type

Interventional

Source

IRCT

Registry ID

IRCT20211213053375N1

Enrollment

Registered

2022-01-22

Start date

2022-04-21

Completion date

Unknown

Last updated

2022-02-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Acetaminophen Poisoning, Hepatotoxicity. Poisoning by and exposure to nonopioid analgesics, antipyretics and antirheumatics, undetermined intent

Interventions

Intervention 1: Control group: Receiving standard treatment of acetaminophen poisoning. Standard treatment is the dosing schedule for the 21-hour IV protocol as follows: Loading dose: 150mg/kg in 200

Eligibility

Sex/Gender

All

Age

18 Years to 75 Years

Inclusion criteria

Inclusion criteria: Consume more than 7.5 grams of acetaminophen Taking acetaminophen with unknown amount and high liver enzymes Toxic levels of acetaminophen according to the Rumack–Matthew nomogram

Exclusion criteria

Exclusion criteria: Previous history of any liver disease Sensitivity to zeolite compounds

Design outcomes

Primary

Measure	Time frame
Normal levels of liver enzymes. Timepoint: Primary outcome is measured following the administration of Zeolive and 14 days after that. Method of measurement: Liver enzyme levels will be measured using the Mindray BS-800.;Normal range of prothrombin time (PT). Timepoint: Primary outcome is measured following the administration of Zeolive and 14 days after that. Method of measurement: Prothrombin time will be determined using the succeeder SF-8100.	—

Measure

Time frame

Normal levels of liver enzymes. Timepoint: Primary outcome is measured following the administration of Zeolive and 14 days after that. Method of measurement: Liver enzyme levels will be measured using the Mindray BS-800.;Normal range of prothrombin time (PT). Timepoint: Primary outcome is measured following the administration of Zeolive and 14 days after that. Method of measurement: Prothrombin time will be determined using the succeeder SF-8100.

—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactShahin Shadnia

Shahid Beheshti University of Medical Sciences

shahin1380@gmail.com+98 21 5541 8175

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026