Breast cancer. Malignant neoplasm of unspecified site of unspecified female breast
Conditions
Interventions
Intervention 1: Intervention group: external irradiation of the whole breast plus boost (photon or electron) is performed. The prescribed dose to isocenter will be 42.5 Gray in 16 fractions or 50 Gray
Sponsors
Ahvaz University of Medical Sciences
Eligibility
Sex/Gender
Female
Age
45 Years to No maximum
Inclusion criteria
Inclusion criteria: Age more than 45 years Unifocal and unicenric breast cancer less than or equal to 3 cm in size (including various histologies of invasive ductal, Papillary, mucinous, tubular, edullary and lobular carcinoma and low to moderate risk intraductal carcinoma) No invasion to the lymphovascular space No lymphatic involvement in invasive histologies No distant metastasis Consent to participate in the study
Exclusion criteria
Exclusion criteria: Extensive Intraductal Component (EIC) in breast imaging evaluation Paget disease of the breast or skin involvement Synchronous tumor or history of breast cancer History of malignancy 5 years before enrollment Pregnancy or lactation History of collagen vascular disease, or genetic diseases such as ataxia Telangiectasia that leads to increased radiation sensitivity
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Serum level of Transforming Growth Factor Beta-1 (TGFB-1). Timepoint: Before radiotherapy, immediately after the end of radiotherapy and three months after the end of radiotherapy. Method of measurement: Assessment of serum levels of TGF-beta1 by Enzyme-linked immunosorbent assay technique (ELISA). | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactMarjan Kouhzad Mohammadi
Ahvaz University of Medical Sciences
Outcome results
None listed