Gastric cancer. Malignant neoplasm of stomach, unspecified
Conditions
Interventions
Intervention group: In total neoadjuvant chemotherapy group, patients will be treated with eight sessions of fluorouracil, leucovorin, oxaliplatin, and docetaxel before surgery. Fluorouracil as a 24-h
Sponsors
Shiraz University of Medical Sciences
Eligibility
Sex/Gender
All
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: Pathologically confirmed gastric adenocarcinoma in biopsy Perigastric lymph node metastasis in CT scan Resectable primary gastric tumor based on CT scan
Exclusion criteria
Exclusion criteria: Presence of distant metastasis at the presentation Previous history of chemotherapy Previous history of radiotherapy Previous history of malignancy Suffering from uncontrolled diabetes mellitus Suffering from uncontrolled hypertension No consent to enroll
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Pathologic response. Timepoint: After the intervention and providing the pathologic report of gastrectomy. Method of measurement: Based on report of pathologist. | — |
Secondary
| Measure | Time frame |
|---|---|
| Surgical margin status. Timepoint: After the intervention and providing the pathologic report of gastrectomy. Method of measurement: Based on pathologist report.;Treatment completion rate. Timepoint: During the intervention, every three week. Method of measurement: History taking.;Treatment toxicity. Timepoint: During the intervention, every three week. Method of measurement: history taking. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactMehrdad Golmoradi
Shiraz University of Medical Sciences
Outcome results
None listed