???? ??? ?? ??????. T28.1 Burn of oesophagus
Conditions
Interventions
Intervention 1: Intervention group:Children in this group will receive early repeated endoscopic brushing. The procedure will start two weeks after caustic substance ingestion and will be performed on
Sponsors
Mashhad University of Medical Sciences
Eligibility
Sex/Gender
All
Age
12 Months to 216 Months
Inclusion criteria
Inclusion criteria: The child is under 18 years of age. There is a history of swallowing a corrosive acid or alkali. Esophageal burns of grade 2B or higher confirmed on initial endoscopy. Written informed consent is obtained from the parent or legal guardian.
Exclusion criteria
Exclusion criteria: Presence of severe active gastrointestinal bleeding. Presence of hemodynamic instability at the time of admission. Presence of severe uncontrolled coagulation disorders. Use of severely immunosuppressive medications at the time of admission.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Occurrence of esophageal stricture: Percentage of children developing esophageal stricture during follow-up.Severity of esophageal stricture based on Savary score: Highest Savary dilator size that can pass through the esophagus without resistance.Procedure-related adverse events: Number and type of adverse events including bleeding, pain, or infection associated with the procedure.Healing of esophageal tissue: Degree of mucosal repair and inflammation reduction based on repeated endoscopic findings. Timepoint: Occurrence of esophageal stricture: Assessed at the end of week 6 after the intervention and during a one-month follow-up visit.Severity of esophageal stricture based on Savary score: Recorded at each dilatation or brushing session (weeks 2, 3, 4, 5, and 6) and during the one-month post-intervention follow-up.Procedure-related adverse events: Documented immediately after each procedure and monitored for up to one week following each session.Healing of esophageal tissue: Assessed by endoscopy at week 6 and at the one-month follow-up visit after the intervention. Method of measurement: Occurrence of esophageal stricture: Diagnosis of esophageal stricture using standard pediatric endoscopy performed by a pediatric gastroenterologist.Severity of esophageal stricture based on Savary score: Determination of the highest Savary dilator size that can pass through the esophagus without resistance, assessed by a pediatric gastroenterologist at each dilatation or brushing session.Procedure-related adverse events: Documentation of adverse events including bleeding, pain, and infection by the responsible physician and nurse during the procedure.Healing of esophageal tissue: Assessment of mucosal repair and reduction of inflammation using repeated endoscopy and photographic reports by the pediatric gastroenterologist. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactMaryam Khalesi
Mashhad University of Medical Sciences
Outcome results
None listed