lidocaine effect on extubation

The effect of intravenous lidocaine on reducing the complications of endotracheal intubation after cardiac surgery

Status

Recruiting

Phases

Unknown

Study type

Interventional

Source

IRCT

Registry ID

IRCT20211206053291N1

Enrollment

Registered

2022-02-20

Start date

2022-01-08

Completion date

Unknown

Last updated

2022-03-08

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Larangospasm.. Postprocedural subglottic stenosis

Interventions

Intervention 1: Intervention group: 45 patients who have weaning and extubation conditions for at least 6 to 12 hours after surgery. For this purpose, the patient should have relatively simple heart s

Eligibility

Sex/Gender

All

Age

18 Years to 85 Years

Inclusion criteria

Inclusion criteria: simple cardiac surgury(CABG or valvular) No history of smoking and drug or alcohol addiction during the last 10 years before surgery No history of any drug or food allergies All patients took beta-blockers around the operation and in the morning No history of lung problems (asthma, COPD, etc.) treated with oral or inhaled drugs

Exclusion criteria

Exclusion criteria: Dangerous arrhythmia during or after surgery Hemodynamic instability including: cardiac instability (patients treated with epinephrine or levofed at doses above 1.1 µg / kg) and respiratory instability (po2=60mmhg or pco2=50) during postoperative time Bleeding so much that the patient becomes a candidate for reoperation Injection of lidocaine for any reason after surgery EF drop after surgery Use of ECMO or pump balloons after surgery

Design outcomes

Primary

Measure	Time frame
Cough occurs after extubation. Timepoint: The onset of cough is assessed before and during injection, 5 minutes after injection, and finally one minute after endotracheal tube removal and 10 minutes after. Method of measurement: The incidence of cough is measured by three criteria of cough, which include: 1- no cough or temporary cough following the exit of the endotracheal tube, 2- incidence of cough by breathing, and 3- persistent cough without respiratory stimulation when the endotracheal tube exits up to 10 minutes later. The questionnaire is mentioned.	—

Measure

Time frame

Cough occurs after extubation. Timepoint: The onset of cough is assessed before and during injection, 5 minutes after injection, and finally one minute after endotracheal tube removal and 10 minutes after. Method of measurement: The incidence of cough is measured by three criteria of cough, which include: 1- no cough or temporary cough following the exit of the endotracheal tube, 2- incidence of cough by breathing, and 3- persistent cough without respiratory stimulation when the endotracheal tube exits up to 10 minutes later. The questionnaire is mentioned.

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactAbdolreza Dayani

Iran University of Medical Sciences

dr.a.dayani@gmail.com+98 21 2266 3250

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026