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Comparison of the Effect of Aprepitant with Ondansetron on PONV

Comparison of the Effect of Aprepitant with Ondansetron on Postoperative Nausea and Vomiting after Orthognathic Surgery

Status
Recruiting
Phases
Phase 2
Study type
Interventional
Source
IRCT
Registry ID
IRCT20211205053279N3
Enrollment
60
Registered
2022-12-16
Start date
2022-12-16
Completion date
Unknown
Last updated
2023-02-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Postoperative Nausea and Vomiting after Orthognathic Surgery. Nausea and vomiting following gastrointestinal surgery

Interventions

Intervention 1: Group 1: One hour before the surgery, a placebo capsule prepared by emptying the aprepitant capsule is given to the patient with a small amount of water. After induction of anesthesia,

Sponsors

Shahid Beheshti University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
All
Age
15 Years to 50 Years

Inclusion criteria

Inclusion criteria: Age 15-50 year American Society of Anesthesiologist physical statous I_II weight 40-90 Kg apfel scale =2 posted for orthognathic surgery under general anaesthesia

Exclusion criteria

Exclusion criteria: Pregnancy/breastfeeding status Allergy to any medications to be used before operation or intra-operatively History of drug abuse Patients with hystory of heart, renal, or hepatic failure

Design outcomes

Primary

MeasureTime frame
The incidence of post operative nausea. Timepoint: Before the intervention, when the patient enters the Post Anesthesia Care Unit, 2 hours after surgery, 6 hours after surgery, 12 hours after surgery, 24 hours after surgery, and 48 hours after surgery. Method of measurement: Verbal rating scale.;The incidence of post operative vomiting. Timepoint: Before the intervention, when the patient enters the Post Anesthesia Care Unit, 2 hours after surgery, 6 hours after surgery, 12 hours after surgery, 24 hours after surgery, and 48 hours after surgery. Method of measurement: Verbal rating scale.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactMostafa Alam

Shahid Beheshti University of Medical Sciences

mostafa_alam@sbmu.ac.ir+98 21 2217 5350

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 7, 2026