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The effect of melatonin on SSRIs-induced sexual dysfunction in depressed patients

Effectiveness of melatonin on sexual dysfunction caused by SSRIs in patients with depression

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
IRCT
Registry ID
IRCT20211202053250N1
Enrollment
90
Registered
2022-01-09
Start date
2022-02-20
Completion date
Unknown
Last updated
2022-01-11

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Sexual Dysfunction Disorder. Other sexual dysfunction not due to a substance or known physiological condition

Interventions

Intervention 1: Intervention group: Tablets containing 3 mg of melatonin daily (once daily) and SSRIs and Buspirone for 8 weeks. Intervention 2: Control group: Placebo tablets with the appearance of m

Sponsors

Mashhad University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
Female
Age
20 Years to 50 Years

Inclusion criteria

Inclusion criteria: Women with depression diagnosed with SSRIs-induced sexual dysfunction Age range 20 to 50 years Patient consent to participate in the study Absence of a bleeding disorder or blood clot such as hemophilia Do not take blood thinners such as warfarin Do not HTN or hypotention Absence of epilepsy or other seizure disorders Do not use drugs to prevent organ transplant rejection Absence of an autoimmune disease Absence of pregnancy and lactation Not Hypersensitivity to melatonin and its derivatives No history of sexual dysfunction Addiction to opium Do not take supplements to improve sexual function

Exclusion criteria

Exclusion criteria: The patient is in menopause Lack of complete cooperation of the patient regarding the use of melatonin or the occurrence of a side effect that should result in discontinuation of melatonin

Design outcomes

Primary

MeasureTime frame
Individual score on the Arizona Sexual Experience Questionnaire. Timepoint: Before the intervention and after the end of the study. Method of measurement: Arizona Sexual Experience Questionnaire.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactMahboubeh Eslamzadeh

Mashhad University of Medical Sciences

eslamzadehmh@mums.ac.ir+98 51 3711 2701

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026