Effectiveness of using leukocyte platelet-rich fibrin to increase keratinized tissue around the tooth in the modified apical reposition flap method

Effectiveness of using leukocyte platelet-rich fibrin to increase keratinized tissue around the tooth in the modified apical reposition flap method: A split-mouth, randomized controlled trial

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20211124053173N1

Enrollment

Registered

2021-12-09

Start date

2021-05-22

Completion date

Unknown

Last updated

2022-01-11

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Less than 2 millimeter of Attached gingiva.

Interventions

Intervention 1: Intervention group: Using the modified apically reposition flap with LPRF membrane to increase the keratinized tissue around tooth. Intervention 2: Control group: Using the modified ap

Eligibility

Sex/Gender

All

Age

18 Years to 70 Years

Inclusion criteria

Inclusion criteria: Inclusion criteria: Age between 18 to 70 years old, patients with less than 2 mm of the attached gingiva at the buccal site; less than 5 mm of vestibular depth, and presence of high frenum pull bilaterally in the mandible.

Exclusion criteria

Exclusion criteria: Exclusion criteria: Patients with plaque index greater than 20%, systemic diseases, pregnancy, and lactation, smoking, alcohol use, gingival recession class 3 or 4 Miller, and probing pocket depth greater than 5 mm.

Design outcomes

Primary

Measure	Time frame
The width and thickness of keratinized tissue. Timepoint: The width and thickness of attached gingiva at baseline and 8 weeks post-op. Method of measurement: Using a periodontal probe.	—

Secondary

Measure	Time frame
Post-operative pain and wound shrinkage. Timepoint: At the baseline and 8 weeks post-op. Method of measurement: A visual analog scale(VAS) questionnaire is used to evaluate the amount of pain after the operation, ranging from 0 (no pain) to 10 (worst pain).To assess the wound shrinkage, the amount of apical placement of the flap at the surgery is compared to the newly attached gingiva gained after 8 weeks.	—

Measure

Time frame

Post-operative pain and wound shrinkage. Timepoint: At the baseline and 8 weeks post-op. Method of measurement: A visual analog scale(VAS) questionnaire is used to evaluate the amount of pain after the operation, ranging from 0 (no pain) to 10 (worst pain).To assess the wound shrinkage, the amount of apical placement of the flap at the surgery is compared to the newly attached gingiva gained after 8 weeks.

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactKamran Lahoorpoor

Hamedan University of Medical Sciences

drkamranor2@gmail.com+98 81 3838 0572

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026