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Investigating the effects of Silymarin in the treatment of neonatal jaundice

Investigating the effects of Silymarin in the treatment of idiopathic hyperbilirubinemia:a randomized,double-blind, placebo-controlled, clinical trial

Status
Recruiting
Phases
Phase 3
Study type
Interventional
Source
IRCT
Registry ID
IRCT20211122053144N1
Enrollment
60
Registered
2022-01-02
Start date
2022-01-10
Completion date
Unknown
Last updated
2022-01-11

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Neonatal jaundice. Neonatal jaundice, unspecified

Interventions

Intervention 1: Intervention group: In the intervention group, in addition to phototherapy, neonates receive from the first day of hospitalization at the rate of 4 mg per kg of body weight every 12 ho

Sponsors

Mashhad University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
All
Age
2 Days to 10 Days

Inclusion criteria

Inclusion criteria: Term neonates who have the AAP criteria for the treatment of hyperbilirubinemia with phototherapy Healthy term neonates who have jaundice from the 2nd to the 10th day of birth and need phototherapy

Exclusion criteria

Exclusion criteria: Neonates with bilirubin level in range of blood exchange The neonate or mother has received phenobarbital Neonates with dehydration, sepsis, pneumonia, anemia, severe weight loss, hypoglycemia, renal failure, heart failure, possible hemolytic or inherited hemolytic disease, neonates with conjugated hyperbilirubinemia, neonates with G6PD, ABO or Rh incompatibility Neonates with a history of jaundice medication from two days before

Design outcomes

Primary

MeasureTime frame
Serum bilirubin. Timepoint: 24,48 and 72 hours after starting phototherapy. Method of measurement: bilirubin kit.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactSara Mohammadzadeh Rezaei

Mashhad University of Medical Sciences

mohammadzadehrs991@mums.ac.ir+98 51 3801 2502

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026