Comparison of Two Types of Brain Magnetic Stimulation for Improving Symptoms in Patients with Obsessive-Compulsive Disorder

A Comparative Study of the Efficacy of Repetitive Transcranial Magnetic Stimulation (rTMS) at 1 Hz and 0.5 Hz in Improving Symptoms of Patients with Obsessive-Compulsive Disorder

Status

Recruiting

Phases

Phase 2

Study type

Interventional

Source

IRCT

Registry ID

IRCT20211121053132N4

Enrollment

Registered

2026-04-15

Start date

2026-04-21

Completion date

Unknown

Last updated

2026-06-01

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Obsessive-compulsive disorder. Obsessive-compulsive disorder

Interventions

Intervention 1: Intervention group: Participants in this group receive repetitive transcranial magnetic stimulation at a frequency of 1 hertz. The intervention consists of 10 treatment sessions every

Eligibility

Sex/Gender

All

Age

18 Years to 65 Years

Inclusion criteria

Inclusion criteria: Patients with a diagnosis of obsessive-compulsive disorder confirmed by a psychiatrist based on DSM-5 criteria inadequate response to at least two selective serotonin reuptake inhibitors (SSRIs) and clomipramine (each administered for at least 6 weeks), non-response to cognitive behavioral therapy (CBT).

Exclusion criteria

Exclusion criteria: uncontrolled psychiatric comorbidities such as major depression or anxiety disorders, significant active medical conditions, history of epilepsy or other neurological disorders, contraindications to transcranial magnetic stimulation (including metallic implants in the head or neck), unwillingness to participate in the study.

Design outcomes

Primary

Measure	Time frame
Change in total score of the Yale Brown Obsessive Compulsive Scale. Timepoint: At baseline before the intervention and at the end of the study after completion of the tenth treatment session. Method of measurement: Yale Brown Obsessive Compulsive Scale administered through interview and scored by the evaluator.	—

Secondary

Measure	Time frame
Total score of the Yale Brown Obsessive Compulsive Scale at the end of the study. Timepoint: At the end of the study after completion of the tenth treatment session. Method of measurement: Yale Brown Obsessive Compulsive Scale administered through interview and scored by the evaluator.;Total score of the Yale Brown Obsessive Compulsive Scale at baseline. Timepoint: At baseline before the intervention. Method of measurement: Yale Brown Obsessive Compulsive Scale administered through interview and scored by the evaluator.	—

Measure

Time frame

Total score of the Yale Brown Obsessive Compulsive Scale at the end of the study. Timepoint: At the end of the study after completion of the tenth treatment session. Method of measurement: Yale Brown Obsessive Compulsive Scale administered through interview and scored by the evaluator.;Total score of the Yale Brown Obsessive Compulsive Scale at baseline. Timepoint: At baseline before the intervention. Method of measurement: Yale Brown Obsessive Compulsive Scale administered through interview and scored by the evaluator.

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactGholamreza Asgari

Esfahan University of Medical Sciences

research@mui.ac.ir+98 31 3668 7898

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Jun 11, 2026