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study of the efficacy of ozone injection on cervical pain

The effect of injection of ozone on Pain and Physical Function of Patients with chronic cervical pain :A double-blind Controlled Randomized Trial with a three Month Follow –up

Status
Active, not recruiting
Phases
Phase 3
Study type
Interventional
Source
IRCT
Registry ID
IRCT20211116053072N2
Enrollment
44
Registered
2025-02-12
Start date
2025-02-19
Completion date
Unknown
Last updated
2025-07-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Chronic cervical pain. Cervical disc disorder with radiculopathy

Interventions

Intervention 1: Intervention group: Patients receiving a dose of 20 µg/ml of ozone or o3. Intervention 2: Control group: The group of patients receiving pure oxygen or O2 group.

Sponsors

Iran University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 65 Years

Inclusion criteria

Inclusion criteria: Patients with diffuse neck pain with minimal pain intensity 4 according to vas criteria At least 3 month of neck pain failure to respond to supportive therapy(such as medication or physiotherapy age 18-65 years old patients with body mass index <30 MRI based on the presence of a disc herniation whose location is associated with symptoms

Exclusion criteria

Exclusion criteria: Presence of acute traumatic injury in the cervical spine as confirmed by a specialist doctor Having a history of previous surgery or injury to the neck and other joints of the upper limbs during the last year pregnancy pain in the shoulder joint The presence of a new fracture in the cervical spine during the last year malignant tumors Participation in sports therapy, manipulation, acupuncture and physiotherapy programs during the last three months Congenital malformation of the spine History of neck surgery or trauma in the past year Injection history during the last 6 months History of any cognitive disease. Fibromyalgia, rheumatoid arthritis Red flag (waking up due to pain, night sweats, weight loss, fever, lower upper limb strength).

Design outcomes

Primary

MeasureTime frame
Patient with cervical pain with a VAS of at least 4. Timepoint: Before intervention. 5 weeks later. 8 weeks later. 12 weeks later. Method of measurement: VAS questionnaire.;Improving performance in patient with cervical pain. Timepoint: Before intervention. 5 weeks later. 8 weeks later. 12 weeks later. Method of measurement: functional tests.

Countries

Iran (Islamic Republic of)

Contacts

Public Contacthanise akbarzade

Iran University of Medical Sciences

Haniseak@gmail.com+98 21 6655 4259

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026