Acute respiratory distress caused by Covid-19. Coronavirus as the cause of diseases classified to other chapters
Conditions
Interventions
Intervention 1: Intervention group: Patients receive morphine with a nebulizer mask immediately after admission to the ward or emergency room. Intervention 2: Control group: Patients receive normal sa
Sponsors
Karaj University of Medical Sciences
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: Age 80-18 years Patients with a definitive diagnosis of Covid-19 based on PCR test within 48 hours after hospitalization Acute moderate respiratory distress syndrome with PaO2 / FiO2 <200 based on Berlin criteria (Force et al., 2012) Patients with severe dyspnea Patients in the end-stages of the disease Lack of proper treatment Patients with consent to participate in the project
Exclusion criteria
Exclusion criteria: Patients with high suspicion / diagnosis of heart failure and unstable angina Existence of severe shock with hemodynamic instability despite increased vascular pressure Severe / undiagnosed lung infection for other reasons (chronic obstructive pulmonary disease, pulmonary fibrosis, lung cancer, bacterial pneumonia ...) Diagnosis of pulmonary hemorrhage Pregnancy / breastfeeding An important cause other than acute respiratory distress for respiratory failure Requires ECMO during the study period He/she is expected to be transferred to another hospital within 72 hours Known allergies to morphine Sensitivity or contraindication to exogenous and endogenous opioids Obesity (BMI>35 kg/m2 ) Patients with dissatisfaction with participating in the project
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Mortality rate. Timepoint: During hospitalization. Method of measurement: Based on the patient's record. | — |
Secondary
| Measure | Time frame |
|---|---|
| Oxygen saturation level. Timepoint: Morphine dose before titration, 2 hours after first titration, 2 hours after second titration, 2 hours after third titration, 2 hours after effective drug titration, 12 hours after effective drug titration, 24 hours after effective drug titration. Method of measurement: Pulse oximetry. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactMohammad Hossein Delshad MD.
Karaj University of Medical Sciences
Outcome results
None listed