Clozapine-resistant schizophrenic patients with clozapine-induced sialorrhea. Schizophrenia
Conditions
Interventions
Intervention 1: Intervention group: In this group, patients are supposed to receive amitriptyline tablets from Iran Daroo Company at a dose of 25 mg first, and if the clozapine-induced sialorrhea comp
Sponsors
Shiraz University of Medical Sciences
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: Patients aged 18 to 65 years with a diagnosis of schizophrenia according to the DSM-V criteria Patients should be receiving clozapine for at least 30 days Patients should have a minimum score of 2 on the TNHS scale for sialorrhea
Exclusion criteria
Exclusion criteria: Development of allergies or history of allergies to amitriptyline, atropine and ipratropium bromide Has an underlying disease such as Parkinson's or cerebral palsy that causes sialorrhea The patient has problems and comorbidities such as untreated constipation or urinary retention or bladder obstruction Concomitant use of drugs such as tricyclic antidepressants and atropine and ipratropium bromide and other anticholinergic drugs Breastfeeding and pregnancy History of diseases such as myasthenia gravis, seizures, cardiac arrhythmias, glaucoma, pyloric obstruction, prostate hypertrophy, renal failure, severe autonomic dysfunction, mental retardation, and paralytic paralysis
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Effectiveness score of amitriptyline in reducing clozapine-induced sialorrhea according to TNHS (Toronto Nocturnal Hypersalivation scale). Timepoint: At the beginning of the study, then daily for 7 days, then on days 14, 21 and 28. Method of measurement: Toronto Nocturnal Hypersalivation scale.;The effectiveness of atropine eye drops in reducing clozapine-induced sialorrhea according to the TNHS Toronto Nocturnal Hypersalivation Scale. Timepoint: At the beginning of the study, then daily for 7 days, then on days 14, 21 and 28. Method of measurement: Toronto Nocturnal Hypersalivation scale.;Effective score of ipratropium bromide nasal spray in reducing clozapine-induced sialorrhea according to TNHS (Toronto Nocturnal Hypersalivation scale). Timepoint: At the beginning of the study, then daily for 7 days, then on days 14, 21 and 28. Method of measurement: TNHS (Toronto Nocturnal Hypersalivation scale). | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactIman Karimzadeh
Shiraz University of Medical Sciences
Outcome results
None listed