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Prophylactic effect of Tranexamic acid in decreasing hemorrhage in elective cesarean section

Evaluation the effect of Tranexamic acid infusion with oxytocin versus oxytocin alone before elective cesarean section in prevention preoperative and post operative hemorrhage in Karaj Kamali Hospital: A randomized clinical trial study

Status
Recruiting
Phases
Phase 3
Study type
Interventional
Source
IRCT
Registry ID
IRCT20211109053019N1
Enrollment
200
Registered
2022-11-26
Start date
2022-11-22
Completion date
Unknown
Last updated
2023-02-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Post partum hemorrhage after elective cesarean section. Postpartum hemorrhage

Interventions

Intervention 1: Intervention group: The person 20 minutes before the operation and incision of the skin will receive 1 g of tranexamic acid diluted in 20 cc of 5% dextrose intravenously. Also after th

Sponsors

Karaj University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
Female
Age
18 Years to No maximum

Inclusion criteria

Inclusion criteria: Singleton pregnancy Age over 18 years old Gestational age over 34 weeks Hemoglobin level before operation over 10 mg/dl Platelets over 100000 Be an elective cesarean section candidate

Exclusion criteria

Exclusion criteria: Emergency cesarean section Age less than 18 years old History of deep vein thrombosis or pulmonary emboli History of arterial thrombosis( pectoralis angina, myocardial infarction or stroke) History of convulsion or epilepsy Any known active cardiovascular or liver or kidney disorder Autoimmune disease Sickle cell disease Severe bleeding disease Placenta previa Placenta accreta spectrum Preeclampsia or eclampsia Gestational hypertension or chronic hypertension Hemolysis or low platelet Intrauterine fetal death Allergy to tranexamic acid Multifetal pregnancy Sever polyhydramnios History of recurrent abortion Uterine fibroma History of rheumatologic disease Varicose veins Pre partum hemorrhage Sever intra abdominal adhesions during surgery Damage to bladder or intestines or other organs during surgery Unsuccessful operative vaginal delivery

Design outcomes

Primary

MeasureTime frame
Measurement of hemoglobin after cesarean section. Timepoint: 24 hours after surgery. Method of measurement: Using laboratory vein blood samples.

Secondary

MeasureTime frame
Post partum hemorrhage. Timepoint: 24 hours after delivery. Method of measurement: Comparison of hemoglobin before and after surgery and using the formula to estimate the amount of bleeding.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactDr Ramesh Baradaran Bagheri

Karaj University of Medical Sciences

elham.ghafarinia@gmail.com+98 26 3222 2021

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026