Comparison of the effect of intravenous magnesium sulfate and labetalol on intraoperative bleeding and postoperative edema and ecchymosis in rhinoplasty

Status

Recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20211108053010N1

Enrollment

Registered

2022-05-28

Start date

2022-05-21

Completion date

Unknown

Last updated

2022-05-30

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Condition 1: Bleeding during rhinoplasty. Condition 2: Edema and ecchymosis after rhinoplasty.

Interventions

Intervention 1: Intervention group: In the sulfate group, 30 to 50 mg / kg intravenous magnesium sulfate is given before induction of anesthesia, and 10 to 20 mg / kg intravenous magnesium sulfate is

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: over 18 years old consent to participate in the study

Exclusion criteria

Exclusion criteria: history of hypertension peripheral vascular problems renal, hepatic or hematologic disorders pregnancy obesity diabetic neuropathy uncontrollable hypertension previous treatment with any antihypertensive drug, opioid or anticoagulant magnesium supplementation consumption Chronic drug drug use such as aspirin allergy to magnesium sulfate, drugs or other drugs under study

Design outcomes

Primary

Measure	Time frame
The amount of bleeding during the operation. Timepoint: End of operation. Method of measurement: Measure lost blood by examining gases and suction.;The rate of ecchymosis. Timepoint: 24 hours and one week after surgery. Method of measurement: Standard tool for scoring degree of ecchymosis.;The amount of edema. Timepoint: 24 hours and one week after surgery. Method of measurement: Standard tool for scoring degree of edema.	—

Measure

Time frame

The amount of bleeding during the operation. Timepoint: End of operation. Method of measurement: Measure lost blood by examining gases and suction.;The rate of ecchymosis. Timepoint: 24 hours and one week after surgery. Method of measurement: Standard tool for scoring degree of ecchymosis.;The amount of edema. Timepoint: 24 hours and one week after surgery. Method of measurement: Standard tool for scoring degree of edema.

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Secondary

Measure	Time frame
Sore throat. Timepoint: Postoperatively and 24 hours after surgery. Method of measurement: 4 degree scale of sore throat.;Headache. Timepoint: 24 hours after surgery. Method of measurement: Question.;Orthostatic hypotension. Timepoint: 24 hours after surgery. Method of measurement: Barometer.;Respiratory depression. Timepoint: 24 hours after surgery. Method of measurement: See the number of breaths per minute.;Surgeon consent. Timepoint: After surgery. Method of measurement: Boezaart criteria.	—

Measure

Time frame

Sore throat. Timepoint: Postoperatively and 24 hours after surgery. Method of measurement: 4 degree scale of sore throat.;Headache. Timepoint: 24 hours after surgery. Method of measurement: Question.;Orthostatic hypotension. Timepoint: 24 hours after surgery. Method of measurement: Barometer.;Respiratory depression. Timepoint: 24 hours after surgery. Method of measurement: See the number of breaths per minute.;Surgeon consent. Timepoint: After surgery. Method of measurement: Boezaart criteria.

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactShaghayegh Rezaeekia

Mazandaran University of Medical Sciences

shaghayeghrezaeekia1375@gmail.com+98 13 3346 9321

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026