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Effect of sustained-release metronidazole in peri-implantitis treatment

Comparison of the effect of local delivery of metronidazole with mechanical debridement in the treatment of peri-implantitis

Status
Recruiting
Phases
Phase 3
Study type
Interventional
Source
IRCT
Registry ID
IRCT20211103052960N1
Enrollment
36
Registered
2021-12-11
Start date
2021-12-16
Completion date
Unknown
Last updated
2022-01-11

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Peri-implantitis. Other endosseous dental implant failure

Interventions

Intervention 1: Intervention group: After local anesthesia (Xylocaine Dental (lidocaine HCl)) and isolation and drying of metronidazole (AEROTEX manufacture by Sina daru pharmaceutical company, Iran)

Sponsors

Tabriz University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
All
Age
20 Years to No maximum

Inclusion criteria

Inclusion criteria: Presence of pre-implant disease No history of pre-implant surgery treatment pocket depth>6 mm Positive bleeding on probing No antibiotics and mouthwash and periodontal treatment in the last 6 weeks Absence of underlying disease PFM Base Restoration

Exclusion criteria

Exclusion criteria: Pregnancy and breastfeeding Allergy to metronidazole Chronic drug use

Design outcomes

Primary

MeasureTime frame
Presence or absence of plaque on tooth and implant surfaces (mesial, distal, buccal and lingual surfaces). Timepoint: 1 and 3 months after the intervention. Method of measurement: Clinical dental examination.;The distance between the gingival margin and the depth of the envelope is in millimeters. Timepoint: 1 and 3 months after the intervention. Method of measurement: Clinical dental examination.;Presence or absence of bleeding after probing. Timepoint: 1 and 3 months after the intervention. Method of measurement: Clinical dental examination.;The distance between the acrylic stent and the depth of the pocket. Timepoint: 1 and 3 months after the intervention. Method of measurement: Clinical dental examination.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactMorteza Nasirzadeh

Tabriz University of Medical Sciences

mortezansrz@yahoo.com+98 41 3479 7216

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026