The effect of moderate arterial blood acidosis during reperfusion in valvular heart surgery. Endocarditis, valve unspecified
Conditions
Sponsors
Shahid Rajaei Cardiovascular Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: Patient consent to study Age over 18 years and under 65 years No history of sternotomy and heart surgery Left ventricular ejection fraction greater than 30% Pulmonary outflow volume with pressure per second (FEV1) greater than 65% in spirometry Hemoglobin above 10 mg per deciliter
Exclusion criteria
Exclusion criteria: Need for drug support (receiving inotropes before starting heart surgery) Having a pacemaker or ICD(Implantable Cardioverter Defibrillator) Having impaired lung function tests for FEV1 less than 40% Having kidney or liver dysfunction
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Type of heart rhythm. Timepoint: After removal of the aortic clamp. Method of measurement: ECG curve shape and heart rate per minute.;Return time of sinus rhythm of the heart. Timepoint: After removal of the aortic clamp. Method of measurement: Minutes.;Need for antiarrhythmic drugs. Timepoint: After removal of the aortic clamp. Method of measurement: Yes or no.;Consumption of inotropic after opening the aortic clamp. Timepoint: After removal of the aortic clamp. Method of measurement: Micrograms per kilogram per hour.;Requires defibrillator. Timepoint: After removal of the aortic clamp. Method of measurement: Yes or no.;Need a pacemaker. Timepoint: After removal of the aortic clamp. Method of measurement: Yes or no.;The amount of lactate. Timepoint: After separation of cardiopulmonary bypass machine. Method of measurement: Mg per liter.;Cardiac enzymes (troponin, Lactate Dehydrogenase and Creatine kinase-MB levels). Timepoint: Before surgery, 12 and 24 hours after surgery. Method of measurement: Micrograms per deciliter.;Heart ejection fraction. Timepoint: Before and after surgery. Method of measurement: Echo of the heart and in percent.;Glutathione peroxidase and superoxide dismutase enzymes. Timepoint: Before the aortic clamp and 5 minutes after the opening of the aortic clamp from the coronary sinus. Method of measurement: coronary sinus blood samples in units per liter.;Malonyl di aldehyde. Timepoint: Before the aortic clamp and 5 minutes after the opening of the aortic clamp from the coronary sinus. Method of measurement: Micromol per deciliter.;Nitric oxide. Timepoint: Before the aortic clamp and 5 minutes after the opening of the aortic clamp from the coronary sinus. Method of measurement: Micromol per deciliter.;Duration of mechanical ventilation. Timepoint: Duration of the patient's arrivalafter surgery to the intensive care unit. Method of measurement: Hour.;Stay in the intensive care unit. Timepoint: Duration of the patient arrival after surgery to the i | — |
Secondary
| Measure | Time frame |
|---|---|
| Blood pressure. Timepoint: During the injection of carbon dioxide. Method of measurement: Mm of mercury. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactAregnia Minasians
Shahid Rajaie cardiovascular, medical and research center
Outcome results
None listed