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Investigating the effect of senna on preparation for colonoscopy

Comparison of two bowel preparation regimens for colonoscopy: high-dose polyethylene glycol versus low-dose polyethylene glycol combined with senna

Status
Active, not recruiting
Phases
Phase 3
Study type
Interventional
Source
IRCT
Registry ID
IRCT20211101052935N1
Enrollment
362
Registered
2022-05-13
Start date
2021-02-28
Completion date
Unknown
Last updated
2022-05-30

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

colonoscopy preparation.

Interventions

Intervention 1: Control group: In this study, all patients will undergo colonoscopy in the afternoon and we will use a split-dose preparation, i.e., administering half of the colon cleansing agent in

Sponsors

Shahid Beheshti University of Medical Sciences
Lead Sponsor
Shahid Beheshti University of Medical Sciences
Collaborator

Eligibility

Sex/Gender
All
Age
18 Years to No maximum

Inclusion criteria

Inclusion criteria: People more than 18 year-old. Giving a written consent. Indications for colorectal cancer screening, include: average-risk screening, increased-risk screening (patients with one or more first degree relative[s] with colorectal cancer [CRC] or colorectal adenomas, hereditary CRC syndromes), positive fecal occult blood test, documented iron deficiency anemia in men or postmenopausal women. Lower gastrointestinal symptoms such as unexplained chronic clinically significant diarrhea, or unexplained involuntary weight loss. Abnormal abdominal imaging such as abnormalities detected on barium enema, abdominal computed tomography and etc.

Exclusion criteria

Exclusion criteria: Hypersensitivity to polyethylene glycol or senna Taking laxatives within one week prior to colonoscopy Previous colonic resection surgery Known or suspected bowel obstruction Prior history of colonoscopy

Design outcomes

Primary

MeasureTime frame
Quality of colon preparation. Timepoint: During colonoscopy (within first 24 hours after use regimens). Method of measurement: Endoscopist report based on BBPS (Boston Bowel Preparation Scale).

Secondary

MeasureTime frame
Adverse effects of preparation regimens. Timepoint: While taking the drug until colonoscopy. Method of measurement: patients report.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactMohsen Rajabnia

Shahid Beheshti University of Medical Sciences

dr.rajabnia@outlook.com+98 21 2243 2560

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026