The effect of vitamin D on recurrence of chronic rhinosinusitis associated with nasal polyposis

Evaluation of the effect of vitamin D on recurrence of chronic rhinosinusitis associated with nasal polyposis after functional endoscopic sinus surgery (Triple blind, Placebo-controlled randomized clinical trial)

Status

Recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20211026052878N1

Enrollment

100

Registered

2021-12-18

Start date

2021-12-11

Completion date

Unknown

Last updated

2022-01-11

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Chronic rhinosinusitis with nasal polyposis. Chronic sinusitis, unspecified

Interventions

Intervention 1: Intervention group: Patients with chronic rhinosinusitis associated with polyposis treated with vitamin D. Both control and intervention groups will be divided into three subgroups. Th

Eligibility

Sex/Gender

All

Age

18 Years to 65 Years

Inclusion criteria

Inclusion criteria: Patients referred to Amiralam Hospital with chronic nasal sinusitis with polyposis

Exclusion criteria

Exclusion criteria: Dissatisfaction Getting Covid 19 and getting vitamin D followed while studying Patients with acute complications of chronic sinusitis Taking immunosuppressive drugs Contraceptive drug use (OCP) Taking Anti TB drugs Patients with active infection Recent hypercalcemia or history of hypercalcemia Get anticonvulsant medicine Nephrolithiasis Recent tanning history Pregnancy Breastfeeding History of malabsorption Vitamin D levels above 80 Continuous vitamin D3 supplementation over 400 units per day Acute exacerbation of acute bacterial sinusitis

Design outcomes

Primary

Measure	Time frame
Patient score in SNOT-22 questionnaire. Timepoint: One month, three months and six months after surgery. Method of measurement: The Sino-Nasal Outcome Test (SNOT-22).;Patient score in Lund-Mackay score of CT scan. Timepoint: One month, three months and six months after surgery. Method of measurement: Lund-Mackay score of CT scan.;Patient score in Lund-Kennedy score. Timepoint: One month, three months and six months after surgery. Method of measurement: Lund-Kennedy score.	—

Measure

Time frame

Patient score in SNOT-22 questionnaire. Timepoint: One month, three months and six months after surgery. Method of measurement: The Sino-Nasal Outcome Test (SNOT-22).;Patient score in Lund-Mackay score of CT scan. Timepoint: One month, three months and six months after surgery. Method of measurement: Lund-Mackay score of CT scan.;Patient score in Lund-Kennedy score. Timepoint: One month, three months and six months after surgery. Method of measurement: Lund-Kennedy score.

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactLeyla Noury

Tehran University of Medical Sciences

leyla.noury@gmail.com+98 21 6670 6106

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026