Diseases of the respiratory system. Acute respiratory failure
Conditions
Interventions
Intervention 1: Intervention group: In this study, mechanical ventilation with TV = 3cc / Kg, RR = 6, PEEP = 5 and FI02 = 1 continues in the intervention group during cardiopulmonary bypass and blood
Sponsors
Rajaie Cardiovascular, Medical and Research Center
Eligibility
Sex/Gender
All
Age
35 Years to No maximum
Inclusion criteria
Inclusion criteria: ? All adult patients with age >35y undergoing elective cardiac valve surgery
Exclusion criteria
Exclusion criteria: patients undergoing emergency surgery Patients undergoing congenital heart surgery Patients undergoing third and more valve resections Patients with coagulation disease Patients undergoing dialysis Patients with pulmonary problems such as COPD who are in stage one and four due to FEV1 ( stage1:mild FEV1=80%? stage2:moderate FEV1 50-79%? stage3:severe FEV130-49% ? stage 4: very severe FEV1 =30% ) Patients with fractional ejection less than 35%, Patients who transfer to the ICU with open sternum In this study, if the surgeon's vision decreases during cardiac surgery due to continued mechanical ventilation, the ventilation will stop and the patient will be excluded from the study Patients who remain intubated for more than 12 hours after transfer to the ICU due to hemodynamic instability patients who are transferred to the operating room for any reason
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Inflammatory cytokines (IL-6, IL-8, IL-10,INT gamma,TNF alph). Timepoint: After induction of anesthesia and placement of the central vein; after separation from cardiopulmonary bypass; after extubation. Method of measurement: Inflammatory cytokines using venous blood samples in operation room and ICU.;Respiratory test. Timepoint: The day before surgery, the seventh day after surgery. Method of measurement: PFT and 6min Walking test before and after surgery. | — |
Secondary
| Measure | Time frame |
|---|---|
| Length of stay in hospital and intensive care unit. Timepoint: After discharge from hospital. Method of measurement: length of stay in hospital and intensive care unit according to patient records. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactFatemeh shima Hadipourzadeh
Iran University of Medical Sciences
Outcome results
None listed