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Comparison between sedating effect of Midazolam and Dexmedetomidine in intubated poisoned patients

Comparison of the sedation effect of Dexmedetomidine and midazolam using the Richmond agitation sedation scale (RASS) in patients admitted to clinical toxicology intensive care unit

Status
Recruiting
Phases
Phase 3
Study type
Interventional
Source
IRCT
Registry ID
IRCT20211022052838N1
Enrollment
60
Registered
2023-06-21
Start date
2023-06-22
Completion date
Unknown
Last updated
2023-06-26

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Sedation before Intubation.

Interventions

Intervention group: Patients admitted to Intensive care unit (ICU) of poisoned patients.

Sponsors

Esfahan University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 80 Years

Inclusion criteria

Inclusion criteria: Patients with American society of anesthesiologist (ASA) class 3 and 4 who are admitted in ICU of poisoned patients Age between 18 to 80 Patients whom are going to be intubated Not taking sedative drugs before admitting to intensive care unit (ICU)

Exclusion criteria

Exclusion criteria: known allergy to any of the drugs used in this study advanced liver disease Serum creatinine level above 200 micromol/liter Unstable angina or acute myocardial infarction patients

Design outcomes

Primary

MeasureTime frame
The amount of sedation caused by drug according to RASS scale. Timepoint: Before intervention and then every 2 hours. Method of measurement: RASS scale system is a known scale in the world that measured the rate of sedation whom admitted to ICU. Scoring points in this scale include -5 to +4 that the +4 point belongs to agitated and aggressive patients who are a threat for ICU personals. the -5 points belongs to the patients who are not responding to voice and physical stimulations and they are not conscious. the rest of points are spectrum between these two scores.;Blood pressure in the admitted patients of ICU. Timepoint: Before intervention and then every 2 hours. Method of measurement: Vital sign monitoring device.;Heart rate. Timepoint: Before intervention and then every 2 hours. Method of measurement: Vital sign monitoring device.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactArman Otroshi

Esfahan University of Medical Sciences

arman_otroshi@yahoo.com+98 31 3651 4261

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026